Selective C–H Olefination of Indolines (C5) and Tetrahydroquinolines (C6) by Pd/S,O-Ligand Catalysis

[Image: see text] Herein, we report a highly selective C–H olefination of directing-group-free indolines (C5) and tetrahydroquinolines (C6) by Pd/S,O-ligand catalysis. In the presence of the S,O-ligand, a wide range of challenging indolines, tetrahydroquinolines, and olefins was efficiently olefinat...

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Detalles Bibliográficos
Autores principales: Jia, Wen-Liang, Westerveld, Nick, Wong, Kit Ming, Morsch, Thomas, Hakkennes, Matthijs, Naksomboon, Kananat, Fernández-Ibáñez, M. Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902280/
https://www.ncbi.nlm.nih.gov/pubmed/31710228
http://dx.doi.org/10.1021/acs.orglett.9b03505
Descripción
Sumario:[Image: see text] Herein, we report a highly selective C–H olefination of directing-group-free indolines (C5) and tetrahydroquinolines (C6) by Pd/S,O-ligand catalysis. In the presence of the S,O-ligand, a wide range of challenging indolines, tetrahydroquinolines, and olefins was efficiently olefinated under mild reaction conditions. The synthetic potential of this methodology was demonstrated by the efficient olefination of several indoline-based natural products.

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