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Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India

Polycystic ovary syndrome (PCOS) is a common endocrine disorder predominantly affecting women of reproductive age. Clinical manifestations are diverse including hyperandrogenism, anovulation, infertility and increased risk of metabolic diseases besides psychosocial dysfunction. This review provides...

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Autores principales: Ganie, Mohammad Ashraf, Vasudevan, Vishnu, Wani, Imtiyaz Ahmad, Baba, Mohammad Salem, Arif, Tasleem, Rashid, Aafia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902362/
https://www.ncbi.nlm.nih.gov/pubmed/31823915
http://dx.doi.org/10.4103/ijmr.IJMR_1937_17
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author Ganie, Mohammad Ashraf
Vasudevan, Vishnu
Wani, Imtiyaz Ahmad
Baba, Mohammad Salem
Arif, Tasleem
Rashid, Aafia
author_facet Ganie, Mohammad Ashraf
Vasudevan, Vishnu
Wani, Imtiyaz Ahmad
Baba, Mohammad Salem
Arif, Tasleem
Rashid, Aafia
author_sort Ganie, Mohammad Ashraf
collection PubMed
description Polycystic ovary syndrome (PCOS) is a common endocrine disorder predominantly affecting women of reproductive age. Clinical manifestations are diverse including hyperandrogenism, anovulation, infertility and increased risk of metabolic diseases besides psychosocial dysfunction. This review provides information on the problem of PCOS in India, its pathophysiology, genetics and an overview of current management options to instigate further research in this field. Prevalence of PCOS in India ranges from 3.7 to 22.5 per cent depending on the population studied and the criteria used for diagnosis. Abnormalities in leptin-adiponectin (adipocyte biology), oxidative stress and autoimmunity are among the mechanisms studied regarding pathogenesis of PCOS. Many candidate gene studies have shown associations with PCOS in various studies. Studies have consistently demonstrated the relationship between the well-known manifestation of hyperandrogenism among Indian PCOS women and the metabolic morbidities including insulin resistance, glucose intolerance and cardiovascular risk. Management of individual components of PCOS can be achieved by medications or surgical methods, though further clarification regarding pathogenesis of PCOS is needed to sharpen our therapeutic armamentarium.
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spelling pubmed-69023622019-12-16 Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India Ganie, Mohammad Ashraf Vasudevan, Vishnu Wani, Imtiyaz Ahmad Baba, Mohammad Salem Arif, Tasleem Rashid, Aafia Indian J Med Res Review Article Polycystic ovary syndrome (PCOS) is a common endocrine disorder predominantly affecting women of reproductive age. Clinical manifestations are diverse including hyperandrogenism, anovulation, infertility and increased risk of metabolic diseases besides psychosocial dysfunction. This review provides information on the problem of PCOS in India, its pathophysiology, genetics and an overview of current management options to instigate further research in this field. Prevalence of PCOS in India ranges from 3.7 to 22.5 per cent depending on the population studied and the criteria used for diagnosis. Abnormalities in leptin-adiponectin (adipocyte biology), oxidative stress and autoimmunity are among the mechanisms studied regarding pathogenesis of PCOS. Many candidate gene studies have shown associations with PCOS in various studies. Studies have consistently demonstrated the relationship between the well-known manifestation of hyperandrogenism among Indian PCOS women and the metabolic morbidities including insulin resistance, glucose intolerance and cardiovascular risk. Management of individual components of PCOS can be achieved by medications or surgical methods, though further clarification regarding pathogenesis of PCOS is needed to sharpen our therapeutic armamentarium. Wolters Kluwer - Medknow 2019-10 /pmc/articles/PMC6902362/ /pubmed/31823915 http://dx.doi.org/10.4103/ijmr.IJMR_1937_17 Text en Copyright: © 2019 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Ganie, Mohammad Ashraf
Vasudevan, Vishnu
Wani, Imtiyaz Ahmad
Baba, Mohammad Salem
Arif, Tasleem
Rashid, Aafia
Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India
title Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India
title_full Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India
title_fullStr Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India
title_full_unstemmed Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India
title_short Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India
title_sort epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in india
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902362/
https://www.ncbi.nlm.nih.gov/pubmed/31823915
http://dx.doi.org/10.4103/ijmr.IJMR_1937_17
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