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Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources
Mesenchymal stem cells (MSCs) derived from different tissues may aid in the regeneration of radiation-induced organ lesions; however, the radiation responses of human MSCs from different sources are unknown. In our study, a comparison of the results from cell proliferation, apoptosis, cell cycle, DN...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902398/ https://www.ncbi.nlm.nih.gov/pubmed/31839760 http://dx.doi.org/10.1177/1559325819893210 |
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author | He, Ningning Xiao, Changyan Sun, Yuxiao Wang, Yan Du, Liqing Feng, Yu Liu, Yang Wang, Qin Ji, Kaihua Wang, Jinhan Zhang, Manman Xu, Chang Liu, Qiang |
author_facet | He, Ningning Xiao, Changyan Sun, Yuxiao Wang, Yan Du, Liqing Feng, Yu Liu, Yang Wang, Qin Ji, Kaihua Wang, Jinhan Zhang, Manman Xu, Chang Liu, Qiang |
author_sort | He, Ningning |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) derived from different tissues may aid in the regeneration of radiation-induced organ lesions; however, the radiation responses of human MSCs from different sources are unknown. In our study, a comparison of the results from cell proliferation, apoptosis, cell cycle, DNA damage, and DNA repair assays consistently showed that MSCs derived from adipose tissue possess a significantly stronger radiation resistance capacity than MSCs derived from umbilical cord and gingival, which is accompanied by a higher level of phosphorylated signal transducer and activator of transcription 3 (Stat3) expression. This reminds us Stat3 could be a potential biomarker of radiation resistance. These findings provide a better understanding of radiation-induced biologic responses in MSCs and may lead to the development of better strategies for stem cell treatment and cancer therapy. |
format | Online Article Text |
id | pubmed-6902398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-69023982019-12-13 Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources He, Ningning Xiao, Changyan Sun, Yuxiao Wang, Yan Du, Liqing Feng, Yu Liu, Yang Wang, Qin Ji, Kaihua Wang, Jinhan Zhang, Manman Xu, Chang Liu, Qiang Dose Response Potential Biomarkers of Radiation Damage Mesenchymal stem cells (MSCs) derived from different tissues may aid in the regeneration of radiation-induced organ lesions; however, the radiation responses of human MSCs from different sources are unknown. In our study, a comparison of the results from cell proliferation, apoptosis, cell cycle, DNA damage, and DNA repair assays consistently showed that MSCs derived from adipose tissue possess a significantly stronger radiation resistance capacity than MSCs derived from umbilical cord and gingival, which is accompanied by a higher level of phosphorylated signal transducer and activator of transcription 3 (Stat3) expression. This reminds us Stat3 could be a potential biomarker of radiation resistance. These findings provide a better understanding of radiation-induced biologic responses in MSCs and may lead to the development of better strategies for stem cell treatment and cancer therapy. SAGE Publications 2019-12-09 /pmc/articles/PMC6902398/ /pubmed/31839760 http://dx.doi.org/10.1177/1559325819893210 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Potential Biomarkers of Radiation Damage He, Ningning Xiao, Changyan Sun, Yuxiao Wang, Yan Du, Liqing Feng, Yu Liu, Yang Wang, Qin Ji, Kaihua Wang, Jinhan Zhang, Manman Xu, Chang Liu, Qiang Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources |
title | Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources |
title_full | Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources |
title_fullStr | Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources |
title_full_unstemmed | Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources |
title_short | Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources |
title_sort | radiation responses of human mesenchymal stem cells derived from different sources |
topic | Potential Biomarkers of Radiation Damage |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902398/ https://www.ncbi.nlm.nih.gov/pubmed/31839760 http://dx.doi.org/10.1177/1559325819893210 |
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