Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway

BACKGROUND: Recent studies have reported that Integrin alpha 2 (ITGA2) plays an essential role in tumor cell proliferation, invasion, metastasis, and angiogenesis. An abnormally expressed ITGA2 correlates with unfavorable prognoses in multiple types of cancer. However, the specific mechanism of how...

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Detalles Bibliográficos
Autores principales: Ren, Dianyun, Zhao, Jingyuan, Sun, Yan, Li, Dan, Meng, Zibo, Wang, Bo, Fan, Ping, Liu, Zhiqiang, Jin, Xin, Wu, Heshui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902401/
https://www.ncbi.nlm.nih.gov/pubmed/31818309
http://dx.doi.org/10.1186/s13046-019-1496-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902401/
https://www.ncbi.nlm.nih.gov/pubmed/31818309
http://dx.doi.org/10.1186/s13046-019-1496-1

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