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Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy
The biggest hurdle to targeted cancer therapy is the inevitable emergence of drug resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most commonly in EGFR-mutant non-small cell lung cancer, secondary resistance mutations on the target kinase domain emerge to diminish...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902404/ https://www.ncbi.nlm.nih.gov/pubmed/31815659 http://dx.doi.org/10.1186/s13045-019-0818-2 |