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Predicting effective drug combinations using gradient tree boosting based on features extracted from drug-protein heterogeneous network

BACKGROUND: Although targeted drugs have contributed to impressive advances in the treatment of cancer patients, their clinical benefits on tumor therapies are greatly limited due to intrinsic and acquired resistance of cancer cells against such drugs. Drug combinations synergistically interfere wit...

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Detalles Bibliográficos
Autores principales:	Liu, Hui, Zhang, Wenhao, Nie, Lixia, Ding, Xiancheng, Luo, Judong, Zou, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902475/ https://www.ncbi.nlm.nih.gov/pubmed/31818267 http://dx.doi.org/10.1186/s12859-019-3288-1

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