IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia

BACKGROUND: Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have previously shown that sustained expression of IL-1β in the hippocampus of APP/PS...

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Detalles Bibliográficos
Autores principales: Rivera-Escalera, Fátima, Pinney, Jonathan J., Owlett, Laura, Ahmed, Hoda, Thakar, Juilee, Olschowka, John A., Elliott, Michael R., O’Banion, M. Kerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902486/
https://www.ncbi.nlm.nih.gov/pubmed/31822279
http://dx.doi.org/10.1186/s12974-019-1645-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902486/
https://www.ncbi.nlm.nih.gov/pubmed/31822279
http://dx.doi.org/10.1186/s12974-019-1645-7

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