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IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia

BACKGROUND: Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have previously shown that sustained expression of IL-1β in the hippocampus of APP/PS...

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Detalles Bibliográficos
Autores principales:	Rivera-Escalera, Fátima, Pinney, Jonathan J., Owlett, Laura, Ahmed, Hoda, Thakar, Juilee, Olschowka, John A., Elliott, Michael R., O’Banion, M. Kerry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902486/ https://www.ncbi.nlm.nih.gov/pubmed/31822279 http://dx.doi.org/10.1186/s12974-019-1645-7

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