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Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study
BACKGROUND: Bone mineral density (BMD) has been positively associated with lung function in patients diagnosed with respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. However, the relationship between BMD and lung function is inconsistent in the general po...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902516/ https://www.ncbi.nlm.nih.gov/pubmed/31818275 http://dx.doi.org/10.1186/s12890-019-1008-2 |
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author | Zeng, Xiang Liu, Dongling Zhao, Xiangmei Chao, Ling Li, Yuchun Li, Huijun Li, Wen Gui, Lihui Wu, Weidong |
author_facet | Zeng, Xiang Liu, Dongling Zhao, Xiangmei Chao, Ling Li, Yuchun Li, Huijun Li, Wen Gui, Lihui Wu, Weidong |
author_sort | Zeng, Xiang |
collection | PubMed |
description | BACKGROUND: Bone mineral density (BMD) has been positively associated with lung function in patients diagnosed with respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. However, the relationship between BMD and lung function is inconsistent in the general population. METHODS: To investigate the association between BMD and lung function in a Chinese general population, a total of 1024 adults aged 40–70 years old from Qiliying (an industrial polluted exposure area) and Langgongmiao (the reference area with non-industrial pollution) were recruited and underwent BMD and spirometry tests. RESULTS: Both BMD and lung function levels were lower in the exposed area compared to the reference area. In addition, BMD and lung function levels were also lower in females compared to males. Both Spearman and partial correlation analyses showed that BMD was positively correlated with FVC and FEV(1). After adjusting linear regression analyses for potential confounding factors, every 0.1 g/cm(2) drop in BMD was associated with 53.0 mL decrease in FVC and 33.5 mL decrease in FEV(1). CONCLUSIONS: A reduction of BMD is associated with lower lung function in a general population from China. |
format | Online Article Text |
id | pubmed-6902516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69025162019-12-11 Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study Zeng, Xiang Liu, Dongling Zhao, Xiangmei Chao, Ling Li, Yuchun Li, Huijun Li, Wen Gui, Lihui Wu, Weidong BMC Pulm Med Research Article BACKGROUND: Bone mineral density (BMD) has been positively associated with lung function in patients diagnosed with respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. However, the relationship between BMD and lung function is inconsistent in the general population. METHODS: To investigate the association between BMD and lung function in a Chinese general population, a total of 1024 adults aged 40–70 years old from Qiliying (an industrial polluted exposure area) and Langgongmiao (the reference area with non-industrial pollution) were recruited and underwent BMD and spirometry tests. RESULTS: Both BMD and lung function levels were lower in the exposed area compared to the reference area. In addition, BMD and lung function levels were also lower in females compared to males. Both Spearman and partial correlation analyses showed that BMD was positively correlated with FVC and FEV(1). After adjusting linear regression analyses for potential confounding factors, every 0.1 g/cm(2) drop in BMD was associated with 53.0 mL decrease in FVC and 33.5 mL decrease in FEV(1). CONCLUSIONS: A reduction of BMD is associated with lower lung function in a general population from China. BioMed Central 2019-12-09 /pmc/articles/PMC6902516/ /pubmed/31818275 http://dx.doi.org/10.1186/s12890-019-1008-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zeng, Xiang Liu, Dongling Zhao, Xiangmei Chao, Ling Li, Yuchun Li, Huijun Li, Wen Gui, Lihui Wu, Weidong Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study |
title | Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study |
title_full | Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study |
title_fullStr | Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study |
title_full_unstemmed | Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study |
title_short | Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study |
title_sort | association of bone mineral density with lung function in a chinese general population: the xinxiang rural cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902516/ https://www.ncbi.nlm.nih.gov/pubmed/31818275 http://dx.doi.org/10.1186/s12890-019-1008-2 |
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