Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function

Multiple clinical studies have shown that bardoxolone methyl, a potent activator of nuclear factor erythroid 2–related factor 2 (Nrf2), is effective in increasing glomerular filtration rate in patients with chronic kidney disease. However, whether an Nrf2 activator can protect tubules from proteinur...

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Detalles Bibliográficos
Autores principales: Nagasu, Hajime, Sogawa, Yuji, Kidokoro, Kengo, Itano, Seiji, Yamamoto, Toshiya, Satoh, Minoru, Sasaki, Tamaki, Suzuki, Takafumi, Yamamoto, Masayuki, Wigley, W. Christian, Proksch, Joel W., Meyer, Colin J., Kashihara, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902727/
https://www.ncbi.nlm.nih.gov/pubmed/31431054
http://dx.doi.org/10.1096/fj.201900217R

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