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Effects of monocyte chemoattractant protein‐1, macrophage inflammatory protein‐1α, and interferon‐α2a on P450 enzymes in human hepatocytes in vitro

Some immunomodulatory agents stimulate the release of cytokines capable of suppressing P450 enzymes and potentially affecting pharmacokinetics of coadministered medications. Cytokines released in response to an immunomodulator in the blood ex vivo can be used to screen for the potential for drug‐dru...

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Detalles Bibliográficos
Autores principales:	Czerwiński, Maciej, Gilligan, Krystal, Westland, Kevin, Ogilvie, Brian W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902742/ https://www.ncbi.nlm.nih.gov/pubmed/31857909 http://dx.doi.org/10.1002/prp2.551

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