A green, economical synthesis of β-ketonitriles and trifunctionalized building blocks from esters and lactones

The acylation of the acetonitrile anion with lactones and esters in ethereal solvents was successfully exploited using inexpensive KOt-Bu to obtain a variety of β-ketonitriles and trifunctionalized building blocks, including useful O-unprotected diols. It was discovered that lactones react to produc...

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Detalles Bibliográficos
Autores principales: Pienaar, Daniel P, Butsi, Kamogelo R, Rousseau, Amanda L, Brady, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902896/
https://www.ncbi.nlm.nih.gov/pubmed/31839839
http://dx.doi.org/10.3762/bjoc.15.287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902896/
https://www.ncbi.nlm.nih.gov/pubmed/31839839
http://dx.doi.org/10.3762/bjoc.15.287

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