Optimizing sgRNA length to improve target specificity and efficiency for the GGTA1 gene using the CRISPR/Cas9 gene editing system

The CRISPR/Cas9 gene editing system has enhanced the development of genetically engineered animals for use in xenotransplantation. Potential limitations to the CRISPR/Cas9 system impacting the development of genetically engineered cells and animals include the creation of off-target mutations. We so...

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Detalles Bibliográficos
Autores principales: Matson, Anders W., Hosny, Nora, Swanson, Zachary A., Hering, Bernhard J., Burlak, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903732/
https://www.ncbi.nlm.nih.gov/pubmed/31821359
http://dx.doi.org/10.1371/journal.pone.0226107

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