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Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains intestinal homeostasis and promotes wound healing and tissue regeneration, which can support the growth of colorectal tumours. Mutations in the adenomatous polyposis coli gene (Apc) are a major driver of familial colorectal...

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Detalles Bibliográficos
Autores principales:	Chen, Yu, Vandereyken, Maud, Newton, Ian P., Moraga, Ignacio, Näthke, Inke S., Swamy, Mahima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903767/ https://www.ncbi.nlm.nih.gov/pubmed/31770366 http://dx.doi.org/10.1371/journal.pbio.3000540

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