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Fatal Nonvariceal Gastrointestinal Bleeding in a Cirrhotic Patient Taking Apixaban with No History of Hemorrhage
This report describes a cirrhotic female patient with no history of bleeding or other gastrointestinal disorder who experienced fatal gastrointestinal bleeding (GIB) after taking apixaban [which is a direct oral anticoagulant (DOAC)] for one month for management of chronic nonvalvular atrial fibrill...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903885/ https://www.ncbi.nlm.nih.gov/pubmed/31886064 http://dx.doi.org/10.7759/cureus.6126 |
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author | Yen, Hung-Wen |
author_facet | Yen, Hung-Wen |
author_sort | Yen, Hung-Wen |
collection | PubMed |
description | This report describes a cirrhotic female patient with no history of bleeding or other gastrointestinal disorder who experienced fatal gastrointestinal bleeding (GIB) after taking apixaban [which is a direct oral anticoagulant (DOAC)] for one month for management of chronic nonvalvular atrial fibrillation. The use of apixaban, coupled with the predilection for hemorrhage in cirrhotic patients, most likely contributed to her fatal GIB. Caution should be exercised in considering apixaban and potentially other members of the DOAC class for the treatment of cirrhotic patients until further research can explore the safety of DOAC therapy in cirrhotic patients. |
format | Online Article Text |
id | pubmed-6903885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-69038852019-12-29 Fatal Nonvariceal Gastrointestinal Bleeding in a Cirrhotic Patient Taking Apixaban with No History of Hemorrhage Yen, Hung-Wen Cureus Hematology This report describes a cirrhotic female patient with no history of bleeding or other gastrointestinal disorder who experienced fatal gastrointestinal bleeding (GIB) after taking apixaban [which is a direct oral anticoagulant (DOAC)] for one month for management of chronic nonvalvular atrial fibrillation. The use of apixaban, coupled with the predilection for hemorrhage in cirrhotic patients, most likely contributed to her fatal GIB. Caution should be exercised in considering apixaban and potentially other members of the DOAC class for the treatment of cirrhotic patients until further research can explore the safety of DOAC therapy in cirrhotic patients. Cureus 2019-11-11 /pmc/articles/PMC6903885/ /pubmed/31886064 http://dx.doi.org/10.7759/cureus.6126 Text en Copyright © 2019, Yen et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Hematology Yen, Hung-Wen Fatal Nonvariceal Gastrointestinal Bleeding in a Cirrhotic Patient Taking Apixaban with No History of Hemorrhage |
title | Fatal Nonvariceal Gastrointestinal Bleeding in a Cirrhotic Patient Taking Apixaban with No History of Hemorrhage |
title_full | Fatal Nonvariceal Gastrointestinal Bleeding in a Cirrhotic Patient Taking Apixaban with No History of Hemorrhage |
title_fullStr | Fatal Nonvariceal Gastrointestinal Bleeding in a Cirrhotic Patient Taking Apixaban with No History of Hemorrhage |
title_full_unstemmed | Fatal Nonvariceal Gastrointestinal Bleeding in a Cirrhotic Patient Taking Apixaban with No History of Hemorrhage |
title_short | Fatal Nonvariceal Gastrointestinal Bleeding in a Cirrhotic Patient Taking Apixaban with No History of Hemorrhage |
title_sort | fatal nonvariceal gastrointestinal bleeding in a cirrhotic patient taking apixaban with no history of hemorrhage |
topic | Hematology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903885/ https://www.ncbi.nlm.nih.gov/pubmed/31886064 http://dx.doi.org/10.7759/cureus.6126 |
work_keys_str_mv | AT yenhungwen fatalnonvaricealgastrointestinalbleedinginacirrhoticpatienttakingapixabanwithnohistoryofhemorrhage |