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Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers

One of the major challenges in developing effective therapeutic strategies for Alzheimer’s disease is understanding how genetic risk factors contribute to neurodegeneration. The apolipoprotein epsilon 4 isoform (APOE4) and variants in the Clusterin (CLU) gene (also known as apolipoprotein J) are ass...

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Detalles Bibliográficos
Autores principales:	Jackson, Rosemary J, Rose, Jamie, Tulloch, Jane, Henstridge, Chris, Smith, Colin, Spires-Jones, Tara L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904249/ https://www.ncbi.nlm.nih.gov/pubmed/31853523 http://dx.doi.org/10.1093/braincomms/fcz003

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