Cargando…

Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination

The NLRP3 inflammasome is a multiprotein oligomer responsible for activation of the inflammatory response by promoting the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. Dysregulation of this inflammasome has been linked to several autoimmune diseases, indicating that NL...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rao, Zebing, Chen, Xin, Wu, Junxian, Xiao, Mengjun, Zhang, Jing, Wang, Binghao, Fang, Lei, Zhang, Hongjie, Wang, Xiaoming, Yang, Shuo, Chen, Yunzi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904361/ https://www.ncbi.nlm.nih.gov/pubmed/31866999 http://dx.doi.org/10.3389/fimmu.2019.02783

Ejemplares similares

Corrigendum: 1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2–Hemeoxygenase-1–HMGB1 Pathway in Macrophages
por: Rao, Zebing, et al.
Publicado: (2018)

1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2–Hemeoxygenase-1–HMGB1 Pathway in Macrophages
por: Rao, Zebing, et al.
Publicado: (2017)

miR-369-3p Modulates Intestinal Inflammatory Response via BRCC3/NLRP3 Inflammasome Axis
por: Scalavino, Viviana, et al.
Publicado: (2023)

Vitamin D3 attenuates SARS‐CoV‐2 nucleocapsid protein‐caused hyperinflammation by inactivating the NLRP3 inflammasome through the VDR‐BRCC3 signaling pathway in vitro and in vivo
por: Chen, Mingliang, et al.
Publicado: (2023)

Knockdown of BRCC3 exerts an anti-tumor effect on cervical cancer in vitro
por: Zhang, Feifang, et al.
Publicado: (2018)

STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection
por: Wang, Wenbiao, et al.
Publicado: (2020)

Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity
por: Sberna, Silvia, et al.
Publicado: (2023)

Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
por: Zheng, Chenxiao, et al.
Publicado: (2023)

Role of NLRP3 inflammasome in diabetes and COVID-19 role of NLRP3 inflammasome in the pathogenesis and treatment of COVID-19 and diabetes NLRP3 inflammasome in diabetes and COVID-19 intervention
por: Zhang, Jiayu, et al.
Publicado: (2023)

Parkin increases the risk of colitis by downregulation of VDR via autophagy-lysosome degradation
por: Ma, Zemeng, et al.
Publicado: (2023)

Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway
por: Gao, Hongliang, et al.
Publicado: (2023)

Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells
por: Ramachandran, Akshaya, et al.
Publicado: (2021)

USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3: USP14 induces deubiquitination of NLRP3
por: Hai, Bao, et al.
Publicado: (2022)

NLRP3 inflammasome activation in response to metals
por: Huang, Wanyi, et al.
Publicado: (2023)

Inhibition of lncRNA NEAT1 protects endothelial cells against hypoxia/reoxygenation-induced NLRP3 inflammasome activation by targeting the miR-204/BRCC3 axis
por: Yao, Tao, et al.
Publicado: (2022)

Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent manner
por: Ran, Xiang-Hong, et al.
Publicado: (2022)

BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro
por: Tu, Ziwei, et al.
Publicado: (2015)

NLRP3 Inflammasome and Inflammatory Bowel Disease
por: Zhen, Yu, et al.
Publicado: (2019)

Munronoid I Ameliorates DSS-Induced Mouse Colitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Via Modulation of NLRP3
por: Ma, Xingyu, et al.
Publicado: (2022)

Insulin Reduces Inflammation by Regulating the Activation of the NLRP3 Inflammasome
por: Chang, Yu-Wei, et al.
Publicado: (2021)

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation
por: Lin, Hsin-Chung, et al.
Publicado: (2021)

The Expression of Inflammasomes NLRP1 and NLRP3, Toll-Like Receptors, and Vitamin D Receptor in Synovial Fibroblasts From Patients With Different Types of Knee Arthritis
por: Sakalyte, Regina, et al.
Publicado: (2022)

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation
por: Rabl, Julius, et al.
Publicado: (2019)

Diabetes Mellitus Promotes the Development of Atherosclerosis: The Role of NLRP3
por: Ye, Jingxue, et al.
Publicado: (2022)

Activation of NLRP3 Inflammasome and Onset of Alzheimer’s Disease
por: Bai, Hua, et al.
Publicado: (2021)

NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: From cryopyrin function to targeted therapies
por: Moltrasio, Chiara, et al.
Publicado: (2022)

USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses
por: Zhang, Na, et al.
Publicado: (2022)

Regulation of NLRP3 Inflammasome by Phosphorylation
por: Song, Nan, et al.
Publicado: (2018)

Pharmacological Inhibitors of the NLRP3 Inflammasome
por: Zahid, Ayesha, et al.
Publicado: (2019)

Role of NLRP3 in the pathogenesis and treatment of gout arthritis
por: Liu, Ya-ru, et al.
Publicado: (2023)

Erianin: A Direct NLRP3 Inhibitor With Remarkable Anti-Inflammatory Activity
por: Zhang, Xinyong, et al.
Publicado: (2021)

1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages
por: Duan, Ao, et al.
Publicado: (2021)

The Role of HDAC6 in Autophagy and NLRP3 Inflammasome
por: Chang, Panpan, et al.
Publicado: (2021)

NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection
por: Wang, Xiaocen, et al.
Publicado: (2018)

Persistent expression of NLRP3 in spinal microglia promotes development of lumbar disc degeneration
por: Wang, Peng, et al.
Publicado: (2022)

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation
por: Xu, Ziwei, et al.
Publicado: (2020)

Role of the NLRP3 Inflammasome: Insights Into Cancer Hallmarks
por: Lin, Ting-Yi, et al.
Publicado: (2021)

NLRP3 Inflammasome in Metabolic-Associated Kidney Diseases: An Update
por: Xiong, Wei, et al.
Publicado: (2021)

BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-κB Signaling Pathway Through Targeting TRAF2
por: Tao, Huangheng, et al.
Publicado: (2021)

DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation
por: Kienes, Ioannis, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3og5sjob06kg2orsv6a9m8vfec