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Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques

To explore the role of whole-lesion histogram analysis of apparent diffusion coefficient (ADC) for discriminating between T stages of rectal carcinoma by comparison of reduced field-of-view (FOV) and conventional DWI techniques. 102 patients with rectal cancer were enrolled in this retrospective stu...

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Autores principales: Peng, Yang, Tang, Hao, Hu, Xuemei, Shen, Yaqi, Kamel, Ihab, Li, Zhen, Hu, Daoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904447/
https://www.ncbi.nlm.nih.gov/pubmed/31822707
http://dx.doi.org/10.1038/s41598-019-55059-0
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author Peng, Yang
Tang, Hao
Hu, Xuemei
Shen, Yaqi
Kamel, Ihab
Li, Zhen
Hu, Daoyu
author_facet Peng, Yang
Tang, Hao
Hu, Xuemei
Shen, Yaqi
Kamel, Ihab
Li, Zhen
Hu, Daoyu
author_sort Peng, Yang
collection PubMed
description To explore the role of whole-lesion histogram analysis of apparent diffusion coefficient (ADC) for discriminating between T stages of rectal carcinoma by comparison of reduced field-of-view (FOV) and conventional DWI techniques. 102 patients with rectal cancer were enrolled in this retrospective study. All patients received preoperative MR scan at 3 T, including reduced and full FOV DWI sequences. Histogram parameters from two DWI methods were calculated and correlated with histological T stage of rectal cancer. The diagnostic performance of individual parameter for differentiating stage pT1-2 and pT3-4 tumors from both DWI techniques was assessed by receiver operating characteristic curve analysis. There were significant differences for the parameters of ADCmean, 50th, 75th, 90th, 95th percentiles, skewness and kurtosis of both DWI sequences in patients with pT1-2 as compared to those with pT3-4 tumors (P < 0.05), in addition to parameters including ADCmin (P = 0.015) and 25th percentile (P = 0.006) from rFOV DWI. Correlations were noted between T staging and above histogram parameters from rFOV DWI (r: −0.741–0.682) and fFOV DWI (r: −0.449–0.449), besides parameters of ADCmin (0.370) and 25th percentile (−0.425) from rFOV DWI. The AUCs of 75th and 90th percentiles from rFOV DWI were significantly higher than that from fFOV DWI (P = 0.0410 and P = 0.0208). The whole-lesion histogram analysis based on rFOV DWI was overall more advantageous than the one based on fFOV DWI in differentiating T staging of rectal cancer and the 90th percentile ADC from rFOV DWI was the value with the highest AUC (0.932).
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spelling pubmed-69044472019-12-13 Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques Peng, Yang Tang, Hao Hu, Xuemei Shen, Yaqi Kamel, Ihab Li, Zhen Hu, Daoyu Sci Rep Article To explore the role of whole-lesion histogram analysis of apparent diffusion coefficient (ADC) for discriminating between T stages of rectal carcinoma by comparison of reduced field-of-view (FOV) and conventional DWI techniques. 102 patients with rectal cancer were enrolled in this retrospective study. All patients received preoperative MR scan at 3 T, including reduced and full FOV DWI sequences. Histogram parameters from two DWI methods were calculated and correlated with histological T stage of rectal cancer. The diagnostic performance of individual parameter for differentiating stage pT1-2 and pT3-4 tumors from both DWI techniques was assessed by receiver operating characteristic curve analysis. There were significant differences for the parameters of ADCmean, 50th, 75th, 90th, 95th percentiles, skewness and kurtosis of both DWI sequences in patients with pT1-2 as compared to those with pT3-4 tumors (P < 0.05), in addition to parameters including ADCmin (P = 0.015) and 25th percentile (P = 0.006) from rFOV DWI. Correlations were noted between T staging and above histogram parameters from rFOV DWI (r: −0.741–0.682) and fFOV DWI (r: −0.449–0.449), besides parameters of ADCmin (0.370) and 25th percentile (−0.425) from rFOV DWI. The AUCs of 75th and 90th percentiles from rFOV DWI were significantly higher than that from fFOV DWI (P = 0.0410 and P = 0.0208). The whole-lesion histogram analysis based on rFOV DWI was overall more advantageous than the one based on fFOV DWI in differentiating T staging of rectal cancer and the 90th percentile ADC from rFOV DWI was the value with the highest AUC (0.932). Nature Publishing Group UK 2019-12-10 /pmc/articles/PMC6904447/ /pubmed/31822707 http://dx.doi.org/10.1038/s41598-019-55059-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Peng, Yang
Tang, Hao
Hu, Xuemei
Shen, Yaqi
Kamel, Ihab
Li, Zhen
Hu, Daoyu
Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques
title Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques
title_full Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques
title_fullStr Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques
title_full_unstemmed Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques
title_short Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques
title_sort rectal cancer invasiveness: whole-lesion diffusion-weighted imaging (dwi) histogram analysis by comparison of reduced field-of-view and conventional dwi techniques
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904447/
https://www.ncbi.nlm.nih.gov/pubmed/31822707
http://dx.doi.org/10.1038/s41598-019-55059-0
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