Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

Emerging evidence suggests that dysregulation of oncogenic pathways requires precise tuning in order for cancer to develop. To test this, we examined the overlap between cis-acting elements of the hypoxia-inducible factor (HIF) pathway and cancer-susceptibility polymorphisms as defined in genome-wid...

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Detalles Bibliográficos
Autores principales: Schmid, Virginia, Lafleur, Veronique N., Lombardi, Olivia, Li, Ran, Salama, Rafik, Colli, Leandro, Choudhry, Hani, Chanock, Stephen, Ratcliffe, Peter J., Mole, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904466/
https://www.ncbi.nlm.nih.gov/pubmed/31822727
http://dx.doi.org/10.1038/s41598-019-55098-7

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