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All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia

Ecotropic virus integration site 1 (EVI1), whose overexpression characterizes a particularly aggressive subtype of acute myeloid leukemia (AML), enhanced anti-leukemic activities of all-trans retinoic acid (atRA) in cell lines and patient samples. However, the drivers of leukemia formation, therapy...

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Detalles Bibliográficos
Autores principales:	Nguyen, Chi Huu, Bauer, Katharina, Hackl, Hubert, Schlerka, Angela, Koller, Elisabeth, Hladik, Anastasiya, Stoiber, Dagmar, Zuber, Johannes, Staber, Philipp B., Hoelbl-Kovacic, Andrea, Purton, Louise E., Grebien, Florian, Wieser, Rotraud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904467/ https://www.ncbi.nlm.nih.gov/pubmed/31822659 http://dx.doi.org/10.1038/s41419-019-2172-2

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