Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway

Disulfide bond-disrupting agents (DDAs) are a new chemical class of agents recently shown to have activity against breast tumors in animal models. Blockade of tumor growth is associated with downregulation of EGFR, HER2, and HER3 and reduced Akt phosphorylation, as well as the induction of endoplasm...

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Detalles Bibliográficos
Autores principales: Wang, Mengxiong, Law, Mary E., Davis, Bradley J., Yaaghubi, Elham, Ghilardi, Amanda F., Ferreira, Renan B., Chiang, Chi-Wu, Guryanova, Olga A., Kopinke, Daniel, Heldermon, Coy D., Castellano, Ronald K., Law, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904486/
https://www.ncbi.nlm.nih.gov/pubmed/31839995
http://dx.doi.org/10.1038/s41420-019-0228-9

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