Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice

Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear. Here we report that in mice, osteoclasts induce sensory innervation in the porous endplates which contributes to spinal hypersensitivity in mice. Sensory innervation of the porous areas of sclerot...

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Detalles Bibliográficos
Autores principales: Ni, Shuangfei, Ling, Zemin, Wang, Xiao, Cao, Yong, Wu, Tianding, Deng, Ruoxian, Crane, Janet L., Skolasky, Richard, Demehri, Shadpour, Zhen, Gehua, Jain, Amit, Wu, Panfeng, Pan, Dayu, Hu, Bo, Lyu, Xiao, Li, Yusheng, Chen, Hao, Qi, Huabin, Guan, Yun, Dong, Xinzhong, Wan, Mei, Zou, Xuenong, Lu, Hongbin, Hu, Jianzhong, Cao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904550/
https://www.ncbi.nlm.nih.gov/pubmed/31822662
http://dx.doi.org/10.1038/s41467-019-13476-9

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