Pannexin 3 ER Ca(2+) channel gating is regulated by phosphorylation at the Serine 68 residue in osteoblast differentiation

Pannexin 3 (Panx3) is a regulator of bone formation. Panx3 forms three distinct functional channels: hemichannels, gap junctions, and endoplasmic reticulum (ER) Ca(2+) channels. However, the gating mechanisms of the Panx3 channels remain unclear. Here, we show that the Panx3 ER Ca(2+) channel is mod...

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Detalles Bibliográficos
Autores principales: Ishikawa, Masaki, Williams, Geneva, Forcinito, Patricia, Ishikawa, Momoko, Petrie, Ryan J., Saito, Kan, Fukumoto, Satoshi, Yamada, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904572/
https://www.ncbi.nlm.nih.gov/pubmed/31822768
http://dx.doi.org/10.1038/s41598-019-55371-9

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