Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease

Leptin has been shown to modulate intestinal inflammation in mice. However, clinical evidence regarding its immune-stimulatory potential in human Crohn’s disease remains sparse. We here describe a patient with the unique combination of acquired generalized lipodystrophy and Crohn’s disease (AGLCD) f...

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Detalles Bibliográficos
Autores principales: Ziegler, Jörn F., Böttcher, Chotima, Letizia, Marilena, Yerinde, Cansu, Wu, Hao, Freise, Inka, Rodriguez-Sillke, Yasmina, Stoyanova, Ani K., Kreis, Martin E., Asbach, Patrick, Kunkel, Desiree, Priller, Josef, Anagnostopoulos, Ioannis, Kühl, Anja A., Miehle, Konstanze, Stumvoll, Michael, Tran, Florian, Fredrich, Broder, Forster, Michael, Franke, Andre, Bojarski, Christian, Glauben, Rainer, Löscher, Britt-Sabina, Siegmund, Britta, Weidinger, Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904732/
https://www.ncbi.nlm.nih.gov/pubmed/31822667
http://dx.doi.org/10.1038/s41467-019-13559-7

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