PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization

The PPP2R2A gene encodes the B55α regulatory subunit of PP2A. Here, we report that PPP2R2A is hemizygously lost in ~42% of prostate adenocarcinomas, correlating with reduced expression, poorer prognosis, and an increased incidence of hemizygous loss (>75%) in metastatic disease. Of note, PPP2R2A...

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Detalles Bibliográficos
Autores principales: Zhao, Ziran, Kurimchak, Alison, Nikonova, Anna S., Feiser, Felicity, Wasserman, Jason S., Fowle, Holly, Varughese, Tinsa, Connors, Megan, Johnson, Katherine, Makhov, Petr, Lindskog, Cecilia, Kolenko, Vladimir M., Golemis, Erica A., Duncan, James S., Graña, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904742/
https://www.ncbi.nlm.nih.gov/pubmed/31822657
http://dx.doi.org/10.1038/s41389-019-0180-9

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