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Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification
Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant int...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904752/ https://www.ncbi.nlm.nih.gov/pubmed/31840004 http://dx.doi.org/10.1038/s41413-019-0075-6 |
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author | Hwang, Charles Marini, Simone Huber, Amanda K. Stepien, David M. Sorkin, Michael Loder, Shawn Pagani, Chase A. Li, John Visser, Noelle D. Vasquez, Kaetlin Garada, Mohamed A. Li, Shuli Xu, Jiajia Hsu, Ching-Yun Yu, Paul B. James, Aaron W. Mishina, Yuji Agarwal, Shailesh Li, Jun Levi, Benjamin |
author_facet | Hwang, Charles Marini, Simone Huber, Amanda K. Stepien, David M. Sorkin, Michael Loder, Shawn Pagani, Chase A. Li, John Visser, Noelle D. Vasquez, Kaetlin Garada, Mohamed A. Li, Shuli Xu, Jiajia Hsu, Ching-Yun Yu, Paul B. James, Aaron W. Mishina, Yuji Agarwal, Shailesh Li, Jun Levi, Benjamin |
author_sort | Hwang, Charles |
collection | PubMed |
description | Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone. Based on these clinical observations, we set out to examine the role of vascular signaling in HO. Vascular endothelial growth factor A (VEGFA) has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis. Our findings, using a validated mouse model of HO, demonstrate that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen. |
format | Online Article Text |
id | pubmed-6904752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69047522019-12-13 Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification Hwang, Charles Marini, Simone Huber, Amanda K. Stepien, David M. Sorkin, Michael Loder, Shawn Pagani, Chase A. Li, John Visser, Noelle D. Vasquez, Kaetlin Garada, Mohamed A. Li, Shuli Xu, Jiajia Hsu, Ching-Yun Yu, Paul B. James, Aaron W. Mishina, Yuji Agarwal, Shailesh Li, Jun Levi, Benjamin Bone Res Article Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone. Based on these clinical observations, we set out to examine the role of vascular signaling in HO. Vascular endothelial growth factor A (VEGFA) has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis. Our findings, using a validated mouse model of HO, demonstrate that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen. Nature Publishing Group UK 2019-12-10 /pmc/articles/PMC6904752/ /pubmed/31840004 http://dx.doi.org/10.1038/s41413-019-0075-6 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hwang, Charles Marini, Simone Huber, Amanda K. Stepien, David M. Sorkin, Michael Loder, Shawn Pagani, Chase A. Li, John Visser, Noelle D. Vasquez, Kaetlin Garada, Mohamed A. Li, Shuli Xu, Jiajia Hsu, Ching-Yun Yu, Paul B. James, Aaron W. Mishina, Yuji Agarwal, Shailesh Li, Jun Levi, Benjamin Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification |
title | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification |
title_full | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification |
title_fullStr | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification |
title_full_unstemmed | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification |
title_short | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification |
title_sort | mesenchymal vegfa induces aberrant differentiation in heterotopic ossification |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904752/ https://www.ncbi.nlm.nih.gov/pubmed/31840004 http://dx.doi.org/10.1038/s41413-019-0075-6 |
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