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Combined in silico and (19)F NMR analysis of 5-fluorouracil metabolism in yeast at low ATP conditions

The cytotoxic effect of 5-fluorouracil (5-FU) on yeast cells is thought to be mainly via a misincorporation of fluoropyrimidines into both RNA and DNA, not only DNA damage via inhibition of thymidylate synthase (TYMS) by fluorodeoxyuridine monophosphate (FdUMP). However, some studies on Saccharomyce...

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Detalles Bibliográficos
Autores principales:	Pawłowski, Piotr H., Szczęsny, Paweł, Rempoła, Bożenna, Poznańska, Anna, Poznański, Jarosław
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904775/ https://www.ncbi.nlm.nih.gov/pubmed/31742586 http://dx.doi.org/10.1042/BSR20192847

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