Primary Central Nervous System Lymphoma in an Immunocompetent Patient Presenting as Multiple Cerebellar Lesions: A Case Report and Review of Literature

Primary central nervous system (CNS) lymphoma (PCNSL) is an uncommon extranodal non-Hodgkin lymphoma often presenting as a single brain lesion within the CNS. On histopathological evaluation of PCNSL a positive CD10, which is frequently observed in systemic diffuse large B-cell lymphoma, is present...

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Autores principales: Galarza Fortuna, Gliceida M., Dvir, Kathrin, Febres-Aldana, Christopher, Schwartz, Michael, Medina, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904776/
https://www.ncbi.nlm.nih.gov/pubmed/31818145
http://dx.doi.org/10.1177/2324709619893548
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author Galarza Fortuna, Gliceida M.
Dvir, Kathrin
Febres-Aldana, Christopher
Schwartz, Michael
Medina, Ana Maria
author_facet Galarza Fortuna, Gliceida M.
Dvir, Kathrin
Febres-Aldana, Christopher
Schwartz, Michael
Medina, Ana Maria
author_sort Galarza Fortuna, Gliceida M.
collection PubMed
description Primary central nervous system (CNS) lymphoma (PCNSL) is an uncommon extranodal non-Hodgkin lymphoma often presenting as a single brain lesion within the CNS. On histopathological evaluation of PCNSL a positive CD10, which is frequently observed in systemic diffuse large B-cell lymphoma, is present in approximately 10% of PCNSL. We describe a case of CD10-positive PCNSL presenting with multiple posterior fossa enhancing lesions in an immunocompetent older woman with a history of breast cancer successfully treated by the RTOG 0227 protocol consisting of pre-irradiation chemotherapy with high-dose methotrexate, rituximab, and temozolomide for 6 cycles, followed by low-dose whole-brain radiation and post-irradiation temozolomide.
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spelling pubmed-69047762019-12-13 Primary Central Nervous System Lymphoma in an Immunocompetent Patient Presenting as Multiple Cerebellar Lesions: A Case Report and Review of Literature Galarza Fortuna, Gliceida M. Dvir, Kathrin Febres-Aldana, Christopher Schwartz, Michael Medina, Ana Maria J Investig Med High Impact Case Rep Case Report Primary central nervous system (CNS) lymphoma (PCNSL) is an uncommon extranodal non-Hodgkin lymphoma often presenting as a single brain lesion within the CNS. On histopathological evaluation of PCNSL a positive CD10, which is frequently observed in systemic diffuse large B-cell lymphoma, is present in approximately 10% of PCNSL. We describe a case of CD10-positive PCNSL presenting with multiple posterior fossa enhancing lesions in an immunocompetent older woman with a history of breast cancer successfully treated by the RTOG 0227 protocol consisting of pre-irradiation chemotherapy with high-dose methotrexate, rituximab, and temozolomide for 6 cycles, followed by low-dose whole-brain radiation and post-irradiation temozolomide. SAGE Publications 2019-12-10 /pmc/articles/PMC6904776/ /pubmed/31818145 http://dx.doi.org/10.1177/2324709619893548 Text en © 2019 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Galarza Fortuna, Gliceida M.
Dvir, Kathrin
Febres-Aldana, Christopher
Schwartz, Michael
Medina, Ana Maria
Primary Central Nervous System Lymphoma in an Immunocompetent Patient Presenting as Multiple Cerebellar Lesions: A Case Report and Review of Literature
title Primary Central Nervous System Lymphoma in an Immunocompetent Patient Presenting as Multiple Cerebellar Lesions: A Case Report and Review of Literature
title_full Primary Central Nervous System Lymphoma in an Immunocompetent Patient Presenting as Multiple Cerebellar Lesions: A Case Report and Review of Literature
title_fullStr Primary Central Nervous System Lymphoma in an Immunocompetent Patient Presenting as Multiple Cerebellar Lesions: A Case Report and Review of Literature
title_full_unstemmed Primary Central Nervous System Lymphoma in an Immunocompetent Patient Presenting as Multiple Cerebellar Lesions: A Case Report and Review of Literature
title_short Primary Central Nervous System Lymphoma in an Immunocompetent Patient Presenting as Multiple Cerebellar Lesions: A Case Report and Review of Literature
title_sort primary central nervous system lymphoma in an immunocompetent patient presenting as multiple cerebellar lesions: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904776/
https://www.ncbi.nlm.nih.gov/pubmed/31818145
http://dx.doi.org/10.1177/2324709619893548
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