Rate of differentiation syndrome in patients based on timing of initial all-trans retinoic acid administration

All-trans-retinoic acid (ATRA) is the standard of care for the management of acute promyelocytic leukemia (APL), but can be associated with differentiation syndrome (DS). Over a seven-year period, we sought to determine the impact of ATRA initiation time on the development of DS. ATRA administration...

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Detalles Bibliográficos
Autores principales: Nauffal, Mary, Werner, Lillian, Ni, Jian, Stone, Richard M., DeAngelo, Daniel J., McDonnell, Anne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904816/
https://www.ncbi.nlm.nih.gov/pubmed/31867205
http://dx.doi.org/10.1016/j.lrr.2019.100189
Descripción
Sumario:All-trans-retinoic acid (ATRA) is the standard of care for the management of acute promyelocytic leukemia (APL), but can be associated with differentiation syndrome (DS). Over a seven-year period, we sought to determine the impact of ATRA initiation time on the development of DS. ATRA administration time had no impact on DS occurrence (p = =0.13), APL risk (p = =0.28) or regimen received (p = =0.1). Patients with higher mean body mass index (BMI) were more likely to develop moderate or severe DS (p = =0.02). Early treatment of APL is essential and maybe strongly considered in patients with elevated BMI.

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