Cargando…
Application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates
The American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) have provided guidelines to assist in the accurate diagnosis of lung disease caused by nontuberculous mycobacteria (NTM). These microbiologic, radiographic, and clinical criteria are considered equally important an...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904831/ https://www.ncbi.nlm.nih.gov/pubmed/31867444 http://dx.doi.org/10.1016/j.jctube.2019.100133 |
_version_ | 1783478062544846848 |
---|---|
author | Ghio, Andrew J. Smith, Genee S. DeFlorio-Barker, Stephanie Messier, Kyle P. Hudgens, Edward Murphy, Mark S. Maillard, Jean-Marie Stout, Jason E. Hilborn, Elizabeth D. |
author_facet | Ghio, Andrew J. Smith, Genee S. DeFlorio-Barker, Stephanie Messier, Kyle P. Hudgens, Edward Murphy, Mark S. Maillard, Jean-Marie Stout, Jason E. Hilborn, Elizabeth D. |
author_sort | Ghio, Andrew J. |
collection | PubMed |
description | The American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) have provided guidelines to assist in the accurate diagnosis of lung disease caused by nontuberculous mycobacteria (NTM). These microbiologic, radiographic, and clinical criteria are considered equally important and all must be met to make the diagnosis of NTM lung disease. To assess the significance of the three criteria, each was evaluated for its contribution to the diagnosis of NTM lung disease in a case series. Laboratory reports of any specimen positive for NTM isolation were collected between January 1, 2006 and December 31, 2010 at a university medical center. Medical records were reviewed in detail using a standardized form. The total number of patients with a culture from any site positive for NTM was 297 while the number from respiratory specimens during the same period was 232 (78%). Samples from two of these patients also yielded M. tuberculosis complex and were excluded. While 128 of the remaining 230 patients (55.7%) in the cohort met the microbiologic criterion for diagnosis of NTM lung disease, 151 (65.6%) and 189 (78.3%) met the radiologic and clinical criteria respectively. Only 78 patients (33.9%) met all three criteria provided by the ATS/IDSA for diagnosis of NTM lung disease. This evaluation reaffirms that defining NTM lung disease using either one or two of the criteria provided by the 2007 ATS/IDSA guidelines may significantly overestimate the number of cases of NTM lung disease. Based on the experience of defining NTM lung disease in this case series, recommendations for modification of the ATS/IDSA guidelines are provided which include expansion of both radiologic patterns and the list of symptoms associated with NTM lung disease. |
format | Online Article Text |
id | pubmed-6904831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69048312019-12-20 Application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates Ghio, Andrew J. Smith, Genee S. DeFlorio-Barker, Stephanie Messier, Kyle P. Hudgens, Edward Murphy, Mark S. Maillard, Jean-Marie Stout, Jason E. Hilborn, Elizabeth D. J Clin Tuberc Other Mycobact Dis Article The American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) have provided guidelines to assist in the accurate diagnosis of lung disease caused by nontuberculous mycobacteria (NTM). These microbiologic, radiographic, and clinical criteria are considered equally important and all must be met to make the diagnosis of NTM lung disease. To assess the significance of the three criteria, each was evaluated for its contribution to the diagnosis of NTM lung disease in a case series. Laboratory reports of any specimen positive for NTM isolation were collected between January 1, 2006 and December 31, 2010 at a university medical center. Medical records were reviewed in detail using a standardized form. The total number of patients with a culture from any site positive for NTM was 297 while the number from respiratory specimens during the same period was 232 (78%). Samples from two of these patients also yielded M. tuberculosis complex and were excluded. While 128 of the remaining 230 patients (55.7%) in the cohort met the microbiologic criterion for diagnosis of NTM lung disease, 151 (65.6%) and 189 (78.3%) met the radiologic and clinical criteria respectively. Only 78 patients (33.9%) met all three criteria provided by the ATS/IDSA for diagnosis of NTM lung disease. This evaluation reaffirms that defining NTM lung disease using either one or two of the criteria provided by the 2007 ATS/IDSA guidelines may significantly overestimate the number of cases of NTM lung disease. Based on the experience of defining NTM lung disease in this case series, recommendations for modification of the ATS/IDSA guidelines are provided which include expansion of both radiologic patterns and the list of symptoms associated with NTM lung disease. Elsevier 2019-11-16 /pmc/articles/PMC6904831/ /pubmed/31867444 http://dx.doi.org/10.1016/j.jctube.2019.100133 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Ghio, Andrew J. Smith, Genee S. DeFlorio-Barker, Stephanie Messier, Kyle P. Hudgens, Edward Murphy, Mark S. Maillard, Jean-Marie Stout, Jason E. Hilborn, Elizabeth D. Application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates |
title | Application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates |
title_full | Application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates |
title_fullStr | Application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates |
title_full_unstemmed | Application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates |
title_short | Application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates |
title_sort | application of diagnostic criteria for non-tuberculous mycobacterial disease to a case series of mycobacterial-positive isolates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904831/ https://www.ncbi.nlm.nih.gov/pubmed/31867444 http://dx.doi.org/10.1016/j.jctube.2019.100133 |
work_keys_str_mv | AT ghioandrewj applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates AT smithgenees applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates AT defloriobarkerstephanie applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates AT messierkylep applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates AT hudgensedward applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates AT murphymarks applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates AT maillardjeanmarie applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates AT stoutjasone applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates AT hilbornelizabethd applicationofdiagnosticcriteriafornontuberculousmycobacterialdiseasetoacaseseriesofmycobacterialpositiveisolates |