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Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis

Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for...

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Autores principales: Caridha, Diana, Vesely, Brian, van Bocxlaer, Katrien, Arana, Byron, Mowbray, Charles E., Rafati, Sima, Uliana, Silvia, Reguera, Rosa, Kreishman-Deitrick, Mara, Sciotti, Richard, Buffet, Pierre, Croft, Simon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904839/
https://www.ncbi.nlm.nih.gov/pubmed/31320296
http://dx.doi.org/10.1016/j.ijpddr.2019.06.003
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author Caridha, Diana
Vesely, Brian
van Bocxlaer, Katrien
Arana, Byron
Mowbray, Charles E.
Rafati, Sima
Uliana, Silvia
Reguera, Rosa
Kreishman-Deitrick, Mara
Sciotti, Richard
Buffet, Pierre
Croft, Simon L.
author_facet Caridha, Diana
Vesely, Brian
van Bocxlaer, Katrien
Arana, Byron
Mowbray, Charles E.
Rafati, Sima
Uliana, Silvia
Reguera, Rosa
Kreishman-Deitrick, Mara
Sciotti, Richard
Buffet, Pierre
Croft, Simon L.
author_sort Caridha, Diana
collection PubMed
description Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for cutaneous leishmaniasis (CL). Here we review the need for new treatments for CL, describe in vitro and in vivo assays, models and approaches taken over the past decade to establish a pathway for the discovery, and pre-clinical development of new drugs for CL. These recent advances include novel mouse models of infection using bioluminescent Leishmania, the introduction of PK/PD approaches to skin infection, and defined pre-clinical candidate profiles.
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spelling pubmed-69048392019-12-20 Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis Caridha, Diana Vesely, Brian van Bocxlaer, Katrien Arana, Byron Mowbray, Charles E. Rafati, Sima Uliana, Silvia Reguera, Rosa Kreishman-Deitrick, Mara Sciotti, Richard Buffet, Pierre Croft, Simon L. Int J Parasitol Drugs Drug Resist Includes articles from the special issue “Novel therapies for cutaneous leishmaniasis”, pp. 106 - 179 Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for cutaneous leishmaniasis (CL). Here we review the need for new treatments for CL, describe in vitro and in vivo assays, models and approaches taken over the past decade to establish a pathway for the discovery, and pre-clinical development of new drugs for CL. These recent advances include novel mouse models of infection using bioluminescent Leishmania, the introduction of PK/PD approaches to skin infection, and defined pre-clinical candidate profiles. Elsevier 2019-06-20 /pmc/articles/PMC6904839/ /pubmed/31320296 http://dx.doi.org/10.1016/j.ijpddr.2019.06.003 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Includes articles from the special issue “Novel therapies for cutaneous leishmaniasis”, pp. 106 - 179
Caridha, Diana
Vesely, Brian
van Bocxlaer, Katrien
Arana, Byron
Mowbray, Charles E.
Rafati, Sima
Uliana, Silvia
Reguera, Rosa
Kreishman-Deitrick, Mara
Sciotti, Richard
Buffet, Pierre
Croft, Simon L.
Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
title Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
title_full Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
title_fullStr Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
title_full_unstemmed Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
title_short Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
title_sort route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
topic Includes articles from the special issue “Novel therapies for cutaneous leishmaniasis”, pp. 106 - 179
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904839/
https://www.ncbi.nlm.nih.gov/pubmed/31320296
http://dx.doi.org/10.1016/j.ijpddr.2019.06.003
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