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Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904839/ https://www.ncbi.nlm.nih.gov/pubmed/31320296 http://dx.doi.org/10.1016/j.ijpddr.2019.06.003 |
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author | Caridha, Diana Vesely, Brian van Bocxlaer, Katrien Arana, Byron Mowbray, Charles E. Rafati, Sima Uliana, Silvia Reguera, Rosa Kreishman-Deitrick, Mara Sciotti, Richard Buffet, Pierre Croft, Simon L. |
author_facet | Caridha, Diana Vesely, Brian van Bocxlaer, Katrien Arana, Byron Mowbray, Charles E. Rafati, Sima Uliana, Silvia Reguera, Rosa Kreishman-Deitrick, Mara Sciotti, Richard Buffet, Pierre Croft, Simon L. |
author_sort | Caridha, Diana |
collection | PubMed |
description | Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for cutaneous leishmaniasis (CL). Here we review the need for new treatments for CL, describe in vitro and in vivo assays, models and approaches taken over the past decade to establish a pathway for the discovery, and pre-clinical development of new drugs for CL. These recent advances include novel mouse models of infection using bioluminescent Leishmania, the introduction of PK/PD approaches to skin infection, and defined pre-clinical candidate profiles. |
format | Online Article Text |
id | pubmed-6904839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69048392019-12-20 Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis Caridha, Diana Vesely, Brian van Bocxlaer, Katrien Arana, Byron Mowbray, Charles E. Rafati, Sima Uliana, Silvia Reguera, Rosa Kreishman-Deitrick, Mara Sciotti, Richard Buffet, Pierre Croft, Simon L. Int J Parasitol Drugs Drug Resist Includes articles from the special issue “Novel therapies for cutaneous leishmaniasis”, pp. 106 - 179 Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for cutaneous leishmaniasis (CL). Here we review the need for new treatments for CL, describe in vitro and in vivo assays, models and approaches taken over the past decade to establish a pathway for the discovery, and pre-clinical development of new drugs for CL. These recent advances include novel mouse models of infection using bioluminescent Leishmania, the introduction of PK/PD approaches to skin infection, and defined pre-clinical candidate profiles. Elsevier 2019-06-20 /pmc/articles/PMC6904839/ /pubmed/31320296 http://dx.doi.org/10.1016/j.ijpddr.2019.06.003 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Includes articles from the special issue “Novel therapies for cutaneous leishmaniasis”, pp. 106 - 179 Caridha, Diana Vesely, Brian van Bocxlaer, Katrien Arana, Byron Mowbray, Charles E. Rafati, Sima Uliana, Silvia Reguera, Rosa Kreishman-Deitrick, Mara Sciotti, Richard Buffet, Pierre Croft, Simon L. Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis |
title | Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis |
title_full | Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis |
title_fullStr | Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis |
title_full_unstemmed | Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis |
title_short | Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis |
title_sort | route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis |
topic | Includes articles from the special issue “Novel therapies for cutaneous leishmaniasis”, pp. 106 - 179 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904839/ https://www.ncbi.nlm.nih.gov/pubmed/31320296 http://dx.doi.org/10.1016/j.ijpddr.2019.06.003 |
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