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Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update

Identification of quantitative trait loci (QTLs) and candidate genes that affect growth intensity is a prerequisite for the marker-assisted selection of economically important traits. The number of QTL studies on sheep is relatively small in comparison to those on cattle and pigs. The current QTL sh...

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Autores principales: Zlobin, Alexander S., Volkova, Natalia A., Borodin, Pavel M., Aksenovich, Tatiana I., Tsepilov, Yakov A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904904/
https://www.ncbi.nlm.nih.gov/pubmed/31893215
http://dx.doi.org/10.5194/aab-62-579-2019
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author Zlobin, Alexander S.
Volkova, Natalia A.
Borodin, Pavel M.
Aksenovich, Tatiana I.
Tsepilov, Yakov A.
author_facet Zlobin, Alexander S.
Volkova, Natalia A.
Borodin, Pavel M.
Aksenovich, Tatiana I.
Tsepilov, Yakov A.
author_sort Zlobin, Alexander S.
collection PubMed
description Identification of quantitative trait loci (QTLs) and candidate genes that affect growth intensity is a prerequisite for the marker-assisted selection of economically important traits. The number of QTL studies on sheep is relatively small in comparison to those on cattle and pigs. The current QTL sheep database – Sheep QTLdb – contains information on 1658 QTLs for 225 different traits. A few genes and markers associated with growth, carcass and meat productivity traits have been reported. The information about QTLs from the Sheep QTLdb cannot be directly used in marker-assisted selection due to the lack of essential information such as effective and reference alleles, the effect direction etc., and it requires manual curation and validation. In this study we performed a comprehensive search for QTLs focusing on single nucleotide polymorphisms (SNPs) associated with growth and meat traits in sheep. The database contains information about 156 SNP–trait associations (123 unique SNPs) and a list of 165 associated genes. The updated information is freely available at https://github.com/Defrag1236/Ovines_2018 (last access: 18 September 2019). This information can be useful for further association studies and preliminary estimation of genetic variability for economically important traits in different breeds.
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spelling pubmed-69049042019-12-31 Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update Zlobin, Alexander S. Volkova, Natalia A. Borodin, Pavel M. Aksenovich, Tatiana I. Tsepilov, Yakov A. Arch Anim Breed Short Communication Identification of quantitative trait loci (QTLs) and candidate genes that affect growth intensity is a prerequisite for the marker-assisted selection of economically important traits. The number of QTL studies on sheep is relatively small in comparison to those on cattle and pigs. The current QTL sheep database – Sheep QTLdb – contains information on 1658 QTLs for 225 different traits. A few genes and markers associated with growth, carcass and meat productivity traits have been reported. The information about QTLs from the Sheep QTLdb cannot be directly used in marker-assisted selection due to the lack of essential information such as effective and reference alleles, the effect direction etc., and it requires manual curation and validation. In this study we performed a comprehensive search for QTLs focusing on single nucleotide polymorphisms (SNPs) associated with growth and meat traits in sheep. The database contains information about 156 SNP–trait associations (123 unique SNPs) and a list of 165 associated genes. The updated information is freely available at https://github.com/Defrag1236/Ovines_2018 (last access: 18 September 2019). This information can be useful for further association studies and preliminary estimation of genetic variability for economically important traits in different breeds. Copernicus GmbH 2019-10-23 /pmc/articles/PMC6904904/ /pubmed/31893215 http://dx.doi.org/10.5194/aab-62-579-2019 Text en Copyright: © 2019 Alexander S. Zlobin et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/
spellingShingle Short Communication
Zlobin, Alexander S.
Volkova, Natalia A.
Borodin, Pavel M.
Aksenovich, Tatiana I.
Tsepilov, Yakov A.
Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update
title Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update
title_full Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update
title_fullStr Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update
title_full_unstemmed Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update
title_short Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update
title_sort recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (ovis aries): an update
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904904/
https://www.ncbi.nlm.nih.gov/pubmed/31893215
http://dx.doi.org/10.5194/aab-62-579-2019
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