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Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion

BACKGROUND: Smokeless tobacco (SLT) usage contributes about 40% of the total tobacco used in India. Among the 28 known carcinogens in SLT, tobacco-specific nitrosamines are considered to be the most potent. This has challenged the metabolic condition leading to a rise in the inflammatory status, hep...

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Autores principales: Khaitan, Tanya, Shukla, Anjani Kumar, Gupta, Prashant, Naik, Shantala R., Verma, Pratik, Kumar, Surender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904959/
https://www.ncbi.nlm.nih.gov/pubmed/31867388
http://dx.doi.org/10.4103/jehp.jehp_6_19
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author Khaitan, Tanya
Shukla, Anjani Kumar
Gupta, Prashant
Naik, Shantala R.
Verma, Pratik
Kumar, Surender
author_facet Khaitan, Tanya
Shukla, Anjani Kumar
Gupta, Prashant
Naik, Shantala R.
Verma, Pratik
Kumar, Surender
author_sort Khaitan, Tanya
collection PubMed
description BACKGROUND: Smokeless tobacco (SLT) usage contributes about 40% of the total tobacco used in India. Among the 28 known carcinogens in SLT, tobacco-specific nitrosamines are considered to be the most potent. This has challenged the metabolic condition leading to a rise in the inflammatory status, hepatic injury, and apoptosis of the liver and thyroid tissues. Therefore, the present study was undertaken to evaluate the adverse effects of SLT on the liver and thyroid and establish a correlation between them in Jharkhand population. MATERIALS AND METHODS: A total of 100 individuals (50 SLT users and 50 healthy individuals) were selected for the study. A complete history was obtained, and clinical examination was done to evaluate any oral mucosal changes. Venous blood samples were taken to analyze the liver function test and thyroid profile. RESULTS: Significant changes were observed in the liver enzyme levels and thyroid profile in SLT users when compared to healthy controls. All the parameters of liver function test had a positive correlation with the form of SLT, whereas thyroid profile had a negative correlation. CONCLUSION: This study might be helpful in creating awareness on the hazards of using SLT among the Indian population as a despicable substitute to smoking tobacco. It also acts as a diagnostic tool and warning alarm in chronic tobacco users.
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spelling pubmed-69049592019-12-20 Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion Khaitan, Tanya Shukla, Anjani Kumar Gupta, Prashant Naik, Shantala R. Verma, Pratik Kumar, Surender J Educ Health Promot Original Article BACKGROUND: Smokeless tobacco (SLT) usage contributes about 40% of the total tobacco used in India. Among the 28 known carcinogens in SLT, tobacco-specific nitrosamines are considered to be the most potent. This has challenged the metabolic condition leading to a rise in the inflammatory status, hepatic injury, and apoptosis of the liver and thyroid tissues. Therefore, the present study was undertaken to evaluate the adverse effects of SLT on the liver and thyroid and establish a correlation between them in Jharkhand population. MATERIALS AND METHODS: A total of 100 individuals (50 SLT users and 50 healthy individuals) were selected for the study. A complete history was obtained, and clinical examination was done to evaluate any oral mucosal changes. Venous blood samples were taken to analyze the liver function test and thyroid profile. RESULTS: Significant changes were observed in the liver enzyme levels and thyroid profile in SLT users when compared to healthy controls. All the parameters of liver function test had a positive correlation with the form of SLT, whereas thyroid profile had a negative correlation. CONCLUSION: This study might be helpful in creating awareness on the hazards of using SLT among the Indian population as a despicable substitute to smoking tobacco. It also acts as a diagnostic tool and warning alarm in chronic tobacco users. Wolters Kluwer - Medknow 2019-11-29 /pmc/articles/PMC6904959/ /pubmed/31867388 http://dx.doi.org/10.4103/jehp.jehp_6_19 Text en Copyright: © 2019 Journal of Education and Health Promotion http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Khaitan, Tanya
Shukla, Anjani Kumar
Gupta, Prashant
Naik, Shantala R.
Verma, Pratik
Kumar, Surender
Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion
title Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion
title_full Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion
title_fullStr Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion
title_full_unstemmed Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion
title_short Liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion
title_sort liver and thyroid profile in educating smokeless tobacco users and its role in oral health promotion
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904959/
https://www.ncbi.nlm.nih.gov/pubmed/31867388
http://dx.doi.org/10.4103/jehp.jehp_6_19
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