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Autophagy activated via GRP78 to alleviate endoplasmic reticulum stress for cell survival in blue light-mediated damage of A2E-laden RPEs

BACKGROUND: Retinal pigment epithelium cells (RPEs) are critical for maintaining retinal homeostasis. Accumulation of age-related lipofuscin, N-retinylidene-N-retinylethanolamine (A2E), makes RPEs vulnerable to blue light-mediated damage, which represents an initial cause of some retinal degenerativ...

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Detalles Bibliográficos
Autores principales:	Feng, Jingyang, Chen, Yuhong, Lu, Bing, Sun, Xiangjun, Zhu, Hong, Sun, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905025/ https://www.ncbi.nlm.nih.gov/pubmed/31823795 http://dx.doi.org/10.1186/s12886-019-1261-4

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