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TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment

BACKGROUND: HIV-1–associated neurocognitive disorders (HAND) progression is related to continued inflammation despite undetectable viral loads and may be caused by early viral proteins expressed by latently infected cells. Astrocytes represent an HIV reservoir in the brain where the early viral neur...

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Detalles Bibliográficos
Autores principales:	Chompre, Gladys, Martinez-Orengo, Neysha, Cruz, Myrella, Porter, James T., Noel, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905066/ https://www.ncbi.nlm.nih.gov/pubmed/31829243 http://dx.doi.org/10.1186/s12974-019-1664-4

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