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Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity

OBJECTIVE: To evaluate the effect of three types of muscular resistance training on adiposity, inflammation levels and insulin activity in Swiss mice with fat-rich diet-induced obesity. METHODS: Lean and obese male Swiss mice were selected and allocated to one of eight groups comprising eight mice e...

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Autores principales: Guedes, Janesca Mansur, Pieri, Bruno Luiz da Silva, Luciano, Thaís Fernandes, Marques, Schérolin de Oliveira, Guglielmo, Luiz Guilherme Antonacci, de Souza, Claudio Teodoro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905165/
https://www.ncbi.nlm.nih.gov/pubmed/31553356
http://dx.doi.org/10.31744/einstein_journal/2020AO4784
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author Guedes, Janesca Mansur
Pieri, Bruno Luiz da Silva
Luciano, Thaís Fernandes
Marques, Schérolin de Oliveira
Guglielmo, Luiz Guilherme Antonacci
de Souza, Claudio Teodoro
author_facet Guedes, Janesca Mansur
Pieri, Bruno Luiz da Silva
Luciano, Thaís Fernandes
Marques, Schérolin de Oliveira
Guglielmo, Luiz Guilherme Antonacci
de Souza, Claudio Teodoro
author_sort Guedes, Janesca Mansur
collection PubMed
description OBJECTIVE: To evaluate the effect of three types of muscular resistance training on adiposity, inflammation levels and insulin activity in Swiss mice with fat-rich diet-induced obesity. METHODS: Lean and obese male Swiss mice were selected and allocated to one of eight groups comprising eight mice each, as follows: standard diet + no training; standard diet + muscular resistance training; standard diet + hypertrophy training; standard diet + strength training; high-fat diet + no training; high-fat diet + muscular resistance training; high-fat diet + hypertrophy training; high-fat diet + strength training. The training protocol consisted of stair climbing for a 10-week period. Blood samples were collected for lactate analysis, glucose level measurement and insulin tolerance test. After euthanasia, adipose tissues were removed and weighed for adiposity index determination. Fragments of epididymal adipose tissue were then embedded for histological analysis or homogenized for tumor necrosis factor alpha level determination using the ELISA method. RESULTS: Ausency of differences in total training volume and blood lactate levels overall emphasize the similarity between the different resistance training protocols. Body weight loss, reduced adipocyte area and lower adiposity index were observed in trained obese mice, regardless of training modality. Different training protocols also improved insulin sensitivity and reduced inflammation levels. CONCLUSION: Resistance training protocols were equally effective in reducing body fat, inflammation levels and insulin resistance in obese mice.
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spelling pubmed-69051652019-12-24 Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity Guedes, Janesca Mansur Pieri, Bruno Luiz da Silva Luciano, Thaís Fernandes Marques, Schérolin de Oliveira Guglielmo, Luiz Guilherme Antonacci de Souza, Claudio Teodoro Einstein (Sao Paulo) Original Article OBJECTIVE: To evaluate the effect of three types of muscular resistance training on adiposity, inflammation levels and insulin activity in Swiss mice with fat-rich diet-induced obesity. METHODS: Lean and obese male Swiss mice were selected and allocated to one of eight groups comprising eight mice each, as follows: standard diet + no training; standard diet + muscular resistance training; standard diet + hypertrophy training; standard diet + strength training; high-fat diet + no training; high-fat diet + muscular resistance training; high-fat diet + hypertrophy training; high-fat diet + strength training. The training protocol consisted of stair climbing for a 10-week period. Blood samples were collected for lactate analysis, glucose level measurement and insulin tolerance test. After euthanasia, adipose tissues were removed and weighed for adiposity index determination. Fragments of epididymal adipose tissue were then embedded for histological analysis or homogenized for tumor necrosis factor alpha level determination using the ELISA method. RESULTS: Ausency of differences in total training volume and blood lactate levels overall emphasize the similarity between the different resistance training protocols. Body weight loss, reduced adipocyte area and lower adiposity index were observed in trained obese mice, regardless of training modality. Different training protocols also improved insulin sensitivity and reduced inflammation levels. CONCLUSION: Resistance training protocols were equally effective in reducing body fat, inflammation levels and insulin resistance in obese mice. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2019-09-16 /pmc/articles/PMC6905165/ /pubmed/31553356 http://dx.doi.org/10.31744/einstein_journal/2020AO4784 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Guedes, Janesca Mansur
Pieri, Bruno Luiz da Silva
Luciano, Thaís Fernandes
Marques, Schérolin de Oliveira
Guglielmo, Luiz Guilherme Antonacci
de Souza, Claudio Teodoro
Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
title Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
title_full Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
title_fullStr Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
title_full_unstemmed Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
title_short Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
title_sort muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905165/
https://www.ncbi.nlm.nih.gov/pubmed/31553356
http://dx.doi.org/10.31744/einstein_journal/2020AO4784
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