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Exercise and Neuroinflammation in Health and Disease
Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces microglia activation, mitochondrial dysfunction, the production of n...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Continence Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905205/ https://www.ncbi.nlm.nih.gov/pubmed/31795607 http://dx.doi.org/10.5213/inj.1938214.107 |
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author | Seo, Dae-Yun Heo, Jun-Won Ko, Jeong Rim Kwak, Hyo-Bum |
author_facet | Seo, Dae-Yun Heo, Jun-Won Ko, Jeong Rim Kwak, Hyo-Bum |
author_sort | Seo, Dae-Yun |
collection | PubMed |
description | Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces microglia activation, mitochondrial dysfunction, the production of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), pro-inflammatory cytokines, and reactive oxygen species. Exercise, which plays an important role in maintaining and improving brain health, might be a highly effective intervention for preventing neuroinflammation-related diseases. Thus, since exercise can improve the neuroimmune response, we hypothesized that exercise would attenuate neuroinflammation-related diseases. In this review, we will highlight (1) the biological mechanisms that underlie AD, PD, ALS, and MS, including the neuroinflammation pathways associated with microglia activation, NF-κB, pro-inflammatory cytokines, mitochondrial dysfunction, and reactive oxygen species, and (2) the role of exercise in neuroinflammation-related neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-6905205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Continence Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-69052052019-12-16 Exercise and Neuroinflammation in Health and Disease Seo, Dae-Yun Heo, Jun-Won Ko, Jeong Rim Kwak, Hyo-Bum Int Neurourol J Review Article Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces microglia activation, mitochondrial dysfunction, the production of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), pro-inflammatory cytokines, and reactive oxygen species. Exercise, which plays an important role in maintaining and improving brain health, might be a highly effective intervention for preventing neuroinflammation-related diseases. Thus, since exercise can improve the neuroimmune response, we hypothesized that exercise would attenuate neuroinflammation-related diseases. In this review, we will highlight (1) the biological mechanisms that underlie AD, PD, ALS, and MS, including the neuroinflammation pathways associated with microglia activation, NF-κB, pro-inflammatory cytokines, mitochondrial dysfunction, and reactive oxygen species, and (2) the role of exercise in neuroinflammation-related neurodegenerative diseases. Korean Continence Society 2019-11 2019-11-30 /pmc/articles/PMC6905205/ /pubmed/31795607 http://dx.doi.org/10.5213/inj.1938214.107 Text en Copyright © 2019 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Seo, Dae-Yun Heo, Jun-Won Ko, Jeong Rim Kwak, Hyo-Bum Exercise and Neuroinflammation in Health and Disease |
title | Exercise and Neuroinflammation in Health and Disease |
title_full | Exercise and Neuroinflammation in Health and Disease |
title_fullStr | Exercise and Neuroinflammation in Health and Disease |
title_full_unstemmed | Exercise and Neuroinflammation in Health and Disease |
title_short | Exercise and Neuroinflammation in Health and Disease |
title_sort | exercise and neuroinflammation in health and disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905205/ https://www.ncbi.nlm.nih.gov/pubmed/31795607 http://dx.doi.org/10.5213/inj.1938214.107 |
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