Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission

Perforin-1, a component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of the c.900C > T PRF1 gene (encoding for perforin-1) polymorphism (rs8858...

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Autores principales: Zupin, Luisa, Polesello, Vania, Kamada, Anselmo Jiro, Gratton, Rossella, Segat, Ludovica, Kuhn, Louise, Crovella, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2019
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905447/
https://www.ncbi.nlm.nih.gov/pubmed/31188937
http://dx.doi.org/10.1590/1678-4685-GMB-2018-0243
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author Zupin, Luisa
Polesello, Vania
Kamada, Anselmo Jiro
Gratton, Rossella
Segat, Ludovica
Kuhn, Louise
Crovella, Sergio
author_facet Zupin, Luisa
Polesello, Vania
Kamada, Anselmo Jiro
Gratton, Rossella
Segat, Ludovica
Kuhn, Louise
Crovella, Sergio
author_sort Zupin, Luisa
collection PubMed
description Perforin-1, a component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of the c.900C > T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. The PRF1 c.900C > T polymorphism was genotyped in 331 children from Zambia using a Taqman probe on a Real Time PCR platform. The PRF1 c.900C > T C/T genotype was more frequent among HIV-1 exposed but non-infected children than in HIV-1 positive cases, and the results were confirmed among children infected during breastfeeding. PRF1 c.900C > T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission.
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spelling pubmed-69054472019-12-13 Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission Zupin, Luisa Polesello, Vania Kamada, Anselmo Jiro Gratton, Rossella Segat, Ludovica Kuhn, Louise Crovella, Sergio Genet Mol Biol Human and Medical Genetics Perforin-1, a component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of the c.900C > T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. The PRF1 c.900C > T polymorphism was genotyped in 331 children from Zambia using a Taqman probe on a Real Time PCR platform. The PRF1 c.900C > T C/T genotype was more frequent among HIV-1 exposed but non-infected children than in HIV-1 positive cases, and the results were confirmed among children infected during breastfeeding. PRF1 c.900C > T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission. Sociedade Brasileira de Genética 2019-11-14 2019 /pmc/articles/PMC6905447/ /pubmed/31188937 http://dx.doi.org/10.1590/1678-4685-GMB-2018-0243 Text en Copyright © 2019, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Human and Medical Genetics
Zupin, Luisa
Polesello, Vania
Kamada, Anselmo Jiro
Gratton, Rossella
Segat, Ludovica
Kuhn, Louise
Crovella, Sergio
Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission
title Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission
title_full Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission
title_fullStr Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission
title_full_unstemmed Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission
title_short Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission
title_sort perforin gene prf1 c.900c> t polymorphism and hiv-1 vertical transmission
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905447/
https://www.ncbi.nlm.nih.gov/pubmed/31188937
http://dx.doi.org/10.1590/1678-4685-GMB-2018-0243
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