Induction of miR 21 impairs the anti-Leishmania response through inhibition of IL-12 in canine splenic leukocytes

Visceral Leishmaniasis is a chronic zoonosis and, if left untreated, can be fatal. Infected dogs have decreased cellular immunity (Th1) and develop a potent humoral response (Th2), which is not effective for elimination of the protozoan. Immune response can be modulated by microRNAs (miRNAs), howeve...

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Detalles Bibliográficos
Autores principales: Melo, Larissa Martins, Bragato, Jaqueline Poleto, Venturin, Gabriela Lovizutto, Rebech, Gabriela Torres, Costa, Sidnei Ferro, Garcia, Leandro Encarnação, Lopes, Flávia Lombardi, Eugênio, Flávia de Rezende, Patto dos Santos, Paulo Sérgio, de Lima, Valéria Marçal Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905561/
https://www.ncbi.nlm.nih.gov/pubmed/31825987
http://dx.doi.org/10.1371/journal.pone.0226192

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