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Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues
Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and car...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioExcel Publishing Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905642/ https://www.ncbi.nlm.nih.gov/pubmed/31844421 http://dx.doi.org/10.7573/dic.2019-9-1 |
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author | Shukla, Ashutosh M Wagle Shukla, Aparna |
author_facet | Shukla, Ashutosh M Wagle Shukla, Aparna |
author_sort | Shukla, Ashutosh M |
collection | PubMed |
description | Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney disease (CKD), oncology, and a variety of nonmalarial infections. These clinical advancements are primarily related to pleiotropic pharmacological actions of these drugs, including immunomodulation, anti-inflammatory properties, and capabilities of inducing autophagy and apoptosis at a cellular level. Historically, many clinical benefits in nonmalarial indications were first recognized through serendipitous observations; however, with numerous ongoing systematic clinical studies, the clinical horizons of these drugs have a promising future. |
format | Online Article Text |
id | pubmed-6905642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioExcel Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-69056422019-12-16 Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues Shukla, Ashutosh M Wagle Shukla, Aparna Drugs Context Review Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney disease (CKD), oncology, and a variety of nonmalarial infections. These clinical advancements are primarily related to pleiotropic pharmacological actions of these drugs, including immunomodulation, anti-inflammatory properties, and capabilities of inducing autophagy and apoptosis at a cellular level. Historically, many clinical benefits in nonmalarial indications were first recognized through serendipitous observations; however, with numerous ongoing systematic clinical studies, the clinical horizons of these drugs have a promising future. BioExcel Publishing Ltd 2019-11-25 /pmc/articles/PMC6905642/ /pubmed/31844421 http://dx.doi.org/10.7573/dic.2019-9-1 Text en Copyright © 2019 Shukla AM, Wagle Shukla A. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission. |
spellingShingle | Review Shukla, Ashutosh M Wagle Shukla, Aparna Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues |
title | Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues |
title_full | Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues |
title_fullStr | Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues |
title_full_unstemmed | Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues |
title_short | Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues |
title_sort | expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905642/ https://www.ncbi.nlm.nih.gov/pubmed/31844421 http://dx.doi.org/10.7573/dic.2019-9-1 |
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