Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia

Sleep disruption is associated with cognitive decline and dementia in older adults; however, the underlying mechanisms are unclear. In rodents, sleep disruption causes microglial activation, inhibition of which improves cognition. However, data from humans are lacking. We studied participants in two...

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Detalles Bibliográficos
Autores principales: Kaneshwaran, Kirusanthy, Olah, Marta, Tasaki, Shinya, Yu, Lei, Bradshaw, Elizabeth M., Schneider, Julie A., Buchman, Aron S., Bennett, David A., De Jager, Philip L., Lim, Andrew S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905859/
https://www.ncbi.nlm.nih.gov/pubmed/31844665
http://dx.doi.org/10.1126/sciadv.aax7331

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