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Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice
Objective: This study evaluated the effects of aerobic, resistance, and combined exercise training on cardiac function and autonomic modulation in female ob/ob mice. Methods: Four-week-old female wild type and obese (ob/ob) mice were divided into five groups (n = 8): control (WT), obese (OB) obese +...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906161/ https://www.ncbi.nlm.nih.gov/pubmed/31866872 http://dx.doi.org/10.3389/fphys.2019.01464 |
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author | Stoyell-Conti, Filipe Fernandes Irigoyen, Maria-Claudia Sartori, Michelle Ribeiro, Amanda Aparecida dos Santos, Fernando Machi, Jacqueline Freire Figueroa, Diego Mendrot Taboas Rodrigues, Bruno De Angelis, Kátia |
author_facet | Stoyell-Conti, Filipe Fernandes Irigoyen, Maria-Claudia Sartori, Michelle Ribeiro, Amanda Aparecida dos Santos, Fernando Machi, Jacqueline Freire Figueroa, Diego Mendrot Taboas Rodrigues, Bruno De Angelis, Kátia |
author_sort | Stoyell-Conti, Filipe Fernandes |
collection | PubMed |
description | Objective: This study evaluated the effects of aerobic, resistance, and combined exercise training on cardiac function and autonomic modulation in female ob/ob mice. Methods: Four-week-old female wild type and obese (ob/ob) mice were divided into five groups (n = 8): control (WT), obese (OB) obese + aerobic training (OBA), obese + resistance training (OBR), and obese + combined training (OBC). The exercise training was performed on treadmill and/or ladder at 40–60% maximum test during 8 weeks. Cardiac function was measured using echo machine. Heart rate variability (HRV) was evaluated in the time and frequency domain. Results: OB group presented higher body weight gain (~600%), glycemia (~44%) and glucose intolerance (~150%), reduction of cardiac vagal modulation, evidenced by a lower RMMSD (~56%), total power and high frequency band, and a higher isovolumic relaxation time (IVRT) (~24%) in relation to the WT group. Aerobic and combined training led to a lower IVRT (OBA: ~14%; OBC: ~14%) and myocardial global index (OBA: ~37%; OBC: ~44%). The OBA group presented an increased in vagal indexes of HRV than the other ob/ob groups. A negative correlation was observed between the delta of aerobic exercise capacity and MPI (r = 0.45; p = 0.002) and exercise capacity and body weight gain (r = 0.39; p = 0.002). Conclusion: Only the obese females underwent to aerobic exercise training showed improvement in cardiac function and HRV. Moreover, the aerobic exercise capacity as well as a greater responsivity to aerobic exercise training is intimately associated with these improvements, reinforcing the importance of aerobic exercise training to this population. |
format | Online Article Text |
id | pubmed-6906161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69061612019-12-20 Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice Stoyell-Conti, Filipe Fernandes Irigoyen, Maria-Claudia Sartori, Michelle Ribeiro, Amanda Aparecida dos Santos, Fernando Machi, Jacqueline Freire Figueroa, Diego Mendrot Taboas Rodrigues, Bruno De Angelis, Kátia Front Physiol Physiology Objective: This study evaluated the effects of aerobic, resistance, and combined exercise training on cardiac function and autonomic modulation in female ob/ob mice. Methods: Four-week-old female wild type and obese (ob/ob) mice were divided into five groups (n = 8): control (WT), obese (OB) obese + aerobic training (OBA), obese + resistance training (OBR), and obese + combined training (OBC). The exercise training was performed on treadmill and/or ladder at 40–60% maximum test during 8 weeks. Cardiac function was measured using echo machine. Heart rate variability (HRV) was evaluated in the time and frequency domain. Results: OB group presented higher body weight gain (~600%), glycemia (~44%) and glucose intolerance (~150%), reduction of cardiac vagal modulation, evidenced by a lower RMMSD (~56%), total power and high frequency band, and a higher isovolumic relaxation time (IVRT) (~24%) in relation to the WT group. Aerobic and combined training led to a lower IVRT (OBA: ~14%; OBC: ~14%) and myocardial global index (OBA: ~37%; OBC: ~44%). The OBA group presented an increased in vagal indexes of HRV than the other ob/ob groups. A negative correlation was observed between the delta of aerobic exercise capacity and MPI (r = 0.45; p = 0.002) and exercise capacity and body weight gain (r = 0.39; p = 0.002). Conclusion: Only the obese females underwent to aerobic exercise training showed improvement in cardiac function and HRV. Moreover, the aerobic exercise capacity as well as a greater responsivity to aerobic exercise training is intimately associated with these improvements, reinforcing the importance of aerobic exercise training to this population. Frontiers Media S.A. 2019-12-05 /pmc/articles/PMC6906161/ /pubmed/31866872 http://dx.doi.org/10.3389/fphys.2019.01464 Text en Copyright © 2019 Stoyell-Conti, Irigoyen, Sartori, Ribeiro, dos Santos, Machi, Figueroa, Rodrigues and De Angelis. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Stoyell-Conti, Filipe Fernandes Irigoyen, Maria-Claudia Sartori, Michelle Ribeiro, Amanda Aparecida dos Santos, Fernando Machi, Jacqueline Freire Figueroa, Diego Mendrot Taboas Rodrigues, Bruno De Angelis, Kátia Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice |
title | Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice |
title_full | Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice |
title_fullStr | Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice |
title_full_unstemmed | Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice |
title_short | Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice |
title_sort | aerobic training is better than resistance training on cardiac function and autonomic modulation in female ob/ob mice |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906161/ https://www.ncbi.nlm.nih.gov/pubmed/31866872 http://dx.doi.org/10.3389/fphys.2019.01464 |
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