Cargando…
Remembering Mechanosensitivity of NMDA Receptors
An increase in post-synaptic Ca(2+) conductance through activation of the ionotropic N-methyl-D-aspartate receptor (NMDAR) and concomitant structural changes are essential for the initiation of long-term potentiation (LTP) and memory formation. Memories can be initiated by coincident events, as occu...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906178/ https://www.ncbi.nlm.nih.gov/pubmed/31866826 http://dx.doi.org/10.3389/fncel.2019.00533 |
_version_ | 1783478300995223552 |
---|---|
author | Johnson, Luke R. Battle, Andrew R. Martinac, Boris |
author_facet | Johnson, Luke R. Battle, Andrew R. Martinac, Boris |
author_sort | Johnson, Luke R. |
collection | PubMed |
description | An increase in post-synaptic Ca(2+) conductance through activation of the ionotropic N-methyl-D-aspartate receptor (NMDAR) and concomitant structural changes are essential for the initiation of long-term potentiation (LTP) and memory formation. Memories can be initiated by coincident events, as occurs in classical conditioning, where the NMDAR can act as a molecular coincidence detector. Binding of glutamate and glycine, together with depolarization of the postsynaptic cell membrane to remove the Mg(2+) channel pore block, results in NMDAR opening for Ca(2+) conductance. Accumulating evidence has implicated both force-from-lipids and protein tethering mechanisms for mechanosensory transduction in NMDAR, which has been demonstrated by both, membrane stretch and application of amphipathic molecules such as arachidonic acid (AA). The contribution of mechanosensitivity to memory formation and consolidation may be to increase activity of the NMDAR leading to facilitated memory formation. In this review we look back at the progress made toward understanding the physiological and pathological role of NMDA receptor channels in mechanobiology of the nervous system and consider these findings in like of their potential functional implications for memory formation. We examine recent studies identifying mechanisms of both NMDAR and other mechanosensitive channels and discuss functional implications including gain control of NMDA opening probability. Mechanobiology is a rapidly growing area of biology with many important implications for understanding form, function and pathology in the nervous system. |
format | Online Article Text |
id | pubmed-6906178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69061782019-12-20 Remembering Mechanosensitivity of NMDA Receptors Johnson, Luke R. Battle, Andrew R. Martinac, Boris Front Cell Neurosci Neuroscience An increase in post-synaptic Ca(2+) conductance through activation of the ionotropic N-methyl-D-aspartate receptor (NMDAR) and concomitant structural changes are essential for the initiation of long-term potentiation (LTP) and memory formation. Memories can be initiated by coincident events, as occurs in classical conditioning, where the NMDAR can act as a molecular coincidence detector. Binding of glutamate and glycine, together with depolarization of the postsynaptic cell membrane to remove the Mg(2+) channel pore block, results in NMDAR opening for Ca(2+) conductance. Accumulating evidence has implicated both force-from-lipids and protein tethering mechanisms for mechanosensory transduction in NMDAR, which has been demonstrated by both, membrane stretch and application of amphipathic molecules such as arachidonic acid (AA). The contribution of mechanosensitivity to memory formation and consolidation may be to increase activity of the NMDAR leading to facilitated memory formation. In this review we look back at the progress made toward understanding the physiological and pathological role of NMDA receptor channels in mechanobiology of the nervous system and consider these findings in like of their potential functional implications for memory formation. We examine recent studies identifying mechanisms of both NMDAR and other mechanosensitive channels and discuss functional implications including gain control of NMDA opening probability. Mechanobiology is a rapidly growing area of biology with many important implications for understanding form, function and pathology in the nervous system. Frontiers Media S.A. 2019-12-05 /pmc/articles/PMC6906178/ /pubmed/31866826 http://dx.doi.org/10.3389/fncel.2019.00533 Text en Copyright © 2019 Johnson, Battle and Martinac. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Johnson, Luke R. Battle, Andrew R. Martinac, Boris Remembering Mechanosensitivity of NMDA Receptors |
title | Remembering Mechanosensitivity of NMDA Receptors |
title_full | Remembering Mechanosensitivity of NMDA Receptors |
title_fullStr | Remembering Mechanosensitivity of NMDA Receptors |
title_full_unstemmed | Remembering Mechanosensitivity of NMDA Receptors |
title_short | Remembering Mechanosensitivity of NMDA Receptors |
title_sort | remembering mechanosensitivity of nmda receptors |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906178/ https://www.ncbi.nlm.nih.gov/pubmed/31866826 http://dx.doi.org/10.3389/fncel.2019.00533 |
work_keys_str_mv | AT johnsonluker rememberingmechanosensitivityofnmdareceptors AT battleandrewr rememberingmechanosensitivityofnmdareceptors AT martinacboris rememberingmechanosensitivityofnmdareceptors |