Cargando…

Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients

Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer’s disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau (pTau) tangles, neuroinflammation and synaptic lo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Metaxas, Athanasios, Thygesen, Camilla, Briting, Sanne R. R., Landau, Anne M., Darvesh, Sultan, Finsen, Bente
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906198/ https://www.ncbi.nlm.nih.gov/pubmed/31866830 http://dx.doi.org/10.3389/fncel.2019.00538

Ejemplares similares

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model
por: Kempf, Stefan J., et al.
Publicado: (2016)

Editorial: Mechanisms, markers and therapeutics of synaptic pathology in Alzheimer's disease
por: Metaxas, Athanasios, et al.
Publicado: (2022)

Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer’s Disease
por: Thomsen, Barbara Blicher, et al.
Publicado: (2021)

Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease
por: Metaxas, Athanasios, et al.
Publicado: (2019)

Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease
por: Metaxas, Athanasios, et al.
Publicado: (2019)

Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APP(SWE)/PS1(ΔE9) Transgenic Mice Implicate Cathepsin Z in Alzheimer’s Disease
por: Thygesen, Camilla, et al.
Publicado: (2018)

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease
por: Dunn, Amy R., et al.
Publicado: (2017)

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission
por: Tokudome, Kentaro, et al.
Publicado: (2016)

Commentary: Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease
por: Rai, Sachchida Nand, et al.
Publicado: (2018)

Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density
por: Yang, Yanghong, et al.
Publicado: (2023)

Synaptic Vesicle Glycoprotein 2A: Features and Functions
por: Rossi, Rachele, et al.
Publicado: (2022)

Integration of postmortem amygdala expression profiling, GWAS, and functional cell culture assays: neuroticism-associated synaptic vesicle glycoprotein 2A (SV2A) gene is regulated by miR-133a and miR-218
por: Jurkiewicz, Magdalena, et al.
Publicado: (2020)

A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release
por: Tokudome, Kentaro, et al.
Publicado: (2016)

TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics
por: Jensen, Pia, et al.
Publicado: (2017)

Levetiracetam Reverses Synaptic Deficits Produced by Overexpression of SV2A
por: Nowack, Amy, et al.
Publicado: (2011)

Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer’s-like disease in mice
por: von Linstow, Christian Ulrich, et al.
Publicado: (2017)

Imaging the effect of ketamine on synaptic density (SV2A) in the living brain
por: Holmes, Sophie E, et al.
Publicado: (2022)

Tumor Necrosis Factor (TNF) Is Required for Spatial Learning and Memory in Male Mice under Physiological, but Not Immune-Challenged Conditions
por: Mygind, Leda, et al.
Publicado: (2021)

Synaptic Vesicle Glycoprotein 2A Is Affected in the Central Nervous System of Mice with Huntington Disease and in the Brain of a Human with Huntington Disease Postmortem
por: Bertoglio, Daniele, et al.
Publicado: (2022)

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors
por: Peng, Lisheng, et al.
Publicado: (2011)

In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET
por: Mecca, Adam P., et al.
Publicado: (2020)

Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles
por: Kaempf, Natalie, et al.
Publicado: (2015)

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
por: Onwordi, Ellis Chika, et al.
Publicado: (2020)

Loss of the Synaptic Vesicle Protein SV2B Results in Reduced Neurotransmission and Altered Synaptic Vesicle Protein Expression in the Retina
por: Morgans, Catherine W., et al.
Publicado: (2009)

The synaptic vesicle proteins SV2, synaptotagmin and synaptophysin are sorted to separate cellular compartments in CHO fibroblasts
Publicado: (1993)

Glycosylation Is Dispensable for Sorting of Synaptotagmin 1 but Is Critical for Targeting of SV2 and Synaptophysin to Recycling Synaptic Vesicles
por: Kwon, Sung E., et al.
Publicado: (2012)

Altered Dopamine Synaptic Markers in Postmortem Brain of Obese Subjects
por: Wu, Chun, et al.
Publicado: (2017)

Sepsis: Changing Definitions, Unchanging Treatment
por: Obonyo, Nchafatso Gikenyi, et al.
Publicado: (2019)

Evaluating the In Vivo Specificity of [(18)F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET
por: Serrano, Maria Elisa, et al.
Publicado: (2019)

O11.3. SYNAPTIC MARKER PROTEIN SV2A IS REDUCED IN SCHIZOPHRENIA IN VIVO AND UNAFFECTED BY ANTIPSYCHOTICS IN RATS
por: Chika Onwordi, Ellis, et al.
Publicado: (2020)

Corrigendum: Sepsis: Changing Definitions, Unchanging Treatment
por: Obonyo, Nchafatso Gikenyi, et al.
Publicado: (2020)

Childhood Pneumonia: What’s Unchanged, and What’s New?
por: Yadav, Krishna Kumar, et al.
Publicado: (2023)

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants
por: Martín-Hernández, David, et al.
Publicado: (2018)

Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ALS/FTD is rescued by SV2 replenishment
por: Jensen, Brigid K, et al.
Publicado: (2020)

Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
por: Scaduto, Pietro, et al.
Publicado: (2020)

Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes
por: Añón-Hidalgo, Juan, et al.
Publicado: (2019)

Dynamics of GnRH Neuron Ionotropic GABA and Glutamate Synaptic Receptors Are Unchanged during Estrogen Positive and Negative Feedback in Female Mice
por: Liu, Xinhuai, et al.
Publicado: (2017)

Copeptin Levels Remain Unchanged during the Menstrual Cycle
por: Blum, Claudine A., et al.
Publicado: (2014)

A young man with an unchanged consolidation in chest CT
por: Zhao, Yang, et al.
Publicado: (2018)

The Innovation: A Journal to See the Unseen and Change the Unchanged
por: Chen, Ke, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p12bls5qg77re6cb7259f11gim