Organoids from the Human Fetal and Adult Pancreas

PURPOSE OF REVIEW: Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine. R...

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Autores principales: Balak, Jeetindra R. A., Juksar, Juri, Carlotti, Françoise, Lo Nigro, Antonio, de Koning, Eelco J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906216/
https://www.ncbi.nlm.nih.gov/pubmed/31828551
http://dx.doi.org/10.1007/s11892-019-1261-z
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author Balak, Jeetindra R. A.
Juksar, Juri
Carlotti, Françoise
Lo Nigro, Antonio
de Koning, Eelco J. P.
author_facet Balak, Jeetindra R. A.
Juksar, Juri
Carlotti, Françoise
Lo Nigro, Antonio
de Koning, Eelco J. P.
author_sort Balak, Jeetindra R. A.
collection PubMed
description PURPOSE OF REVIEW: Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine. RECENT FINDINGS: Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses. SUMMARY: Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.
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spelling pubmed-69062162019-12-26 Organoids from the Human Fetal and Adult Pancreas Balak, Jeetindra R. A. Juksar, Juri Carlotti, Françoise Lo Nigro, Antonio de Koning, Eelco J. P. Curr Diab Rep Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors) PURPOSE OF REVIEW: Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine. RECENT FINDINGS: Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses. SUMMARY: Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening. Springer US 2019-12-11 2019 /pmc/articles/PMC6906216/ /pubmed/31828551 http://dx.doi.org/10.1007/s11892-019-1261-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)
Balak, Jeetindra R. A.
Juksar, Juri
Carlotti, Françoise
Lo Nigro, Antonio
de Koning, Eelco J. P.
Organoids from the Human Fetal and Adult Pancreas
title Organoids from the Human Fetal and Adult Pancreas
title_full Organoids from the Human Fetal and Adult Pancreas
title_fullStr Organoids from the Human Fetal and Adult Pancreas
title_full_unstemmed Organoids from the Human Fetal and Adult Pancreas
title_short Organoids from the Human Fetal and Adult Pancreas
title_sort organoids from the human fetal and adult pancreas
topic Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906216/
https://www.ncbi.nlm.nih.gov/pubmed/31828551
http://dx.doi.org/10.1007/s11892-019-1261-z
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