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Mechanisms of suppression of cell growth by dual inhibition of ALK and MEK in ALK-positive non-small cell lung cancer

Anaplastic lymphoma kinase (ALK) rearrangement, a key oncogenic driver in a small subset of non-small cell lung cancers, confers sensitivity to ALK tyrosine kinase inhibitors (TKIs). Crizotinib, a first generation ALK-TKI, has superiority to standard chemotherapy with longer progression-free surviva...

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Detalles Bibliográficos
Autores principales:	Shrestha, N., Nimick, M., Dass, P., Rosengren, R. J., Ashton, J. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906283/ https://www.ncbi.nlm.nih.gov/pubmed/31827192 http://dx.doi.org/10.1038/s41598-019-55376-4

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