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Trained immunity modulates inflammation-induced fibrosis
Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or low-dose LPS stimulation on macrophage phenotype, cyt...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906311/ https://www.ncbi.nlm.nih.gov/pubmed/31827093 http://dx.doi.org/10.1038/s41467-019-13636-x |
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author | Jeljeli, Mohamed Riccio, Luiza Gama Coelho Doridot, Ludivine Chêne, Charlotte Nicco, Carole Chouzenoux, Sandrine Deletang, Quentin Allanore, Yannick Kavian, Niloufar Batteux, Frédéric |
author_facet | Jeljeli, Mohamed Riccio, Luiza Gama Coelho Doridot, Ludivine Chêne, Charlotte Nicco, Carole Chouzenoux, Sandrine Deletang, Quentin Allanore, Yannick Kavian, Niloufar Batteux, Frédéric |
author_sort | Jeljeli, Mohamed |
collection | PubMed |
description | Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or low-dose LPS stimulation on macrophage phenotype, cytokine production, chromatin and metabolic modifications. Low-dose LPS training alleviates fibrosis and inflammation in a mouse model of systemic sclerosis (SSc), whereas BCG-training exacerbates disease in this model. Adoptive transfer of low-dose LPS-trained or BCG-trained macrophages also has beneficial or harmful effects, respectively. Furthermore, coculture with low-dose LPS trained macrophages reduces the fibro-inflammatory profile of fibroblasts from mice and patients with SSc, indicating that trained immunity might be a phenomenon that can be targeted to treat SSc and other autoimmune and inflammatory fibrotic disorders. |
format | Online Article Text |
id | pubmed-6906311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69063112019-12-13 Trained immunity modulates inflammation-induced fibrosis Jeljeli, Mohamed Riccio, Luiza Gama Coelho Doridot, Ludivine Chêne, Charlotte Nicco, Carole Chouzenoux, Sandrine Deletang, Quentin Allanore, Yannick Kavian, Niloufar Batteux, Frédéric Nat Commun Article Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or low-dose LPS stimulation on macrophage phenotype, cytokine production, chromatin and metabolic modifications. Low-dose LPS training alleviates fibrosis and inflammation in a mouse model of systemic sclerosis (SSc), whereas BCG-training exacerbates disease in this model. Adoptive transfer of low-dose LPS-trained or BCG-trained macrophages also has beneficial or harmful effects, respectively. Furthermore, coculture with low-dose LPS trained macrophages reduces the fibro-inflammatory profile of fibroblasts from mice and patients with SSc, indicating that trained immunity might be a phenomenon that can be targeted to treat SSc and other autoimmune and inflammatory fibrotic disorders. Nature Publishing Group UK 2019-12-11 /pmc/articles/PMC6906311/ /pubmed/31827093 http://dx.doi.org/10.1038/s41467-019-13636-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jeljeli, Mohamed Riccio, Luiza Gama Coelho Doridot, Ludivine Chêne, Charlotte Nicco, Carole Chouzenoux, Sandrine Deletang, Quentin Allanore, Yannick Kavian, Niloufar Batteux, Frédéric Trained immunity modulates inflammation-induced fibrosis |
title | Trained immunity modulates inflammation-induced fibrosis |
title_full | Trained immunity modulates inflammation-induced fibrosis |
title_fullStr | Trained immunity modulates inflammation-induced fibrosis |
title_full_unstemmed | Trained immunity modulates inflammation-induced fibrosis |
title_short | Trained immunity modulates inflammation-induced fibrosis |
title_sort | trained immunity modulates inflammation-induced fibrosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906311/ https://www.ncbi.nlm.nih.gov/pubmed/31827093 http://dx.doi.org/10.1038/s41467-019-13636-x |
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