Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation

Metabolism is a critical regulator of cell fate determination. Recently, the significance of metabolic reprogramming in environmental adaptation during tumorigenesis has attracted much attention in cancer research. Recurrent mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes have been iden...

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Detalles Bibliográficos
Autores principales: Fujiwara, Hiroaki, Tateishi, Keisuke, Misumi, Kento, Hayashi, Akimasa, Igarashi, Kaori, Kato, Hiroyuki, Nakatsuka, Takuma, Suzuki, Nobumi, Yamamoto, Keisuke, Kudo, Yotaro, Hayakawa, Yoku, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Kogure, Hirofumi, Nakai, Yosuke, Isayama, Hiroyuki, Hasegawa, Kiyoshi, Fukayama, Masashi, Soga, Tomoyoshi, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906335/
https://www.ncbi.nlm.nih.gov/pubmed/31827136
http://dx.doi.org/10.1038/s41598-019-55211-w

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