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Evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis

BACKGROUND: Processing speed is frequently reduced in patients suffering from multiple sclerosis (MS). Reduced processing speed can also lead to impaired working memory capacity (WMC) in adult MS patients. Less is known about the interplay of cognitive deficits in paediatric MS patients. OBJECTIVES:...

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Autores principales: Kapanci, Tugba, Rostásy, Kevin, Häusler, Martin Georg, Geis, Tobias, Schimmel, Mareike, Elpers, Christiane, Kreth, Jonas H., Thiels, Charlotte, Troche, Stefan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906347/
https://www.ncbi.nlm.nih.gov/pubmed/31853370
http://dx.doi.org/10.1177/2055217319894365
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author Kapanci, Tugba
Rostásy, Kevin
Häusler, Martin Georg
Geis, Tobias
Schimmel, Mareike
Elpers, Christiane
Kreth, Jonas H.
Thiels, Charlotte
Troche, Stefan J
author_facet Kapanci, Tugba
Rostásy, Kevin
Häusler, Martin Georg
Geis, Tobias
Schimmel, Mareike
Elpers, Christiane
Kreth, Jonas H.
Thiels, Charlotte
Troche, Stefan J
author_sort Kapanci, Tugba
collection PubMed
description BACKGROUND: Processing speed is frequently reduced in patients suffering from multiple sclerosis (MS). Reduced processing speed can also lead to impaired working memory capacity (WMC) in adult MS patients. Less is known about the interplay of cognitive deficits in paediatric MS patients. OBJECTIVES: In the present study, we investigated whether processing speed and WMC are reduced in paediatric MS patients compared with healthy controls and whether reduced processing speed and WMC might explain potential differences in psychometric intelligence between MS patients and healthy controls. METHODS: Twenty-one paediatric MS patients and 21 healthy controls completed a reaction time (RT) task, a working memory task, and Cattell’s Culture Fair Test (CFT20-R). RESULTS: Patients with MS had slower RT and lower intelligence scores than healthy controls. We could find no significant differences for WMC. An analysis of covariance revealed that group differences in intelligence could be partially explained by processing speed differences. CONCLUSION: The results indicate that processing speed is a good marker for MS-related impaired efficiency and increased error-proneness of the central nervous system in higher-order cognition as required by Cattell’s CFT20-R.
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spelling pubmed-69063472019-12-18 Evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis Kapanci, Tugba Rostásy, Kevin Häusler, Martin Georg Geis, Tobias Schimmel, Mareike Elpers, Christiane Kreth, Jonas H. Thiels, Charlotte Troche, Stefan J Mult Scler J Exp Transl Clin Original Research Paper BACKGROUND: Processing speed is frequently reduced in patients suffering from multiple sclerosis (MS). Reduced processing speed can also lead to impaired working memory capacity (WMC) in adult MS patients. Less is known about the interplay of cognitive deficits in paediatric MS patients. OBJECTIVES: In the present study, we investigated whether processing speed and WMC are reduced in paediatric MS patients compared with healthy controls and whether reduced processing speed and WMC might explain potential differences in psychometric intelligence between MS patients and healthy controls. METHODS: Twenty-one paediatric MS patients and 21 healthy controls completed a reaction time (RT) task, a working memory task, and Cattell’s Culture Fair Test (CFT20-R). RESULTS: Patients with MS had slower RT and lower intelligence scores than healthy controls. We could find no significant differences for WMC. An analysis of covariance revealed that group differences in intelligence could be partially explained by processing speed differences. CONCLUSION: The results indicate that processing speed is a good marker for MS-related impaired efficiency and increased error-proneness of the central nervous system in higher-order cognition as required by Cattell’s CFT20-R. SAGE Publications 2019-12-11 /pmc/articles/PMC6906347/ /pubmed/31853370 http://dx.doi.org/10.1177/2055217319894365 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Paper
Kapanci, Tugba
Rostásy, Kevin
Häusler, Martin Georg
Geis, Tobias
Schimmel, Mareike
Elpers, Christiane
Kreth, Jonas H.
Thiels, Charlotte
Troche, Stefan J
Evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis
title Evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis
title_full Evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis
title_fullStr Evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis
title_full_unstemmed Evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis
title_short Evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis
title_sort evaluating the relationship between psychometric intelligence and cognitive functions in paediatric multiple sclerosis
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906347/
https://www.ncbi.nlm.nih.gov/pubmed/31853370
http://dx.doi.org/10.1177/2055217319894365
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