DNA methylation directs microRNA biogenesis in mammalian cells

MicroRNA (miRNA) biogenesis initiates co-transcriptionally, but how the Microprocessor machinery pinpoints the locations of short precursor miRNA sequences within long flanking regions of the transcript is not known. Here we show that miRNA biogenesis depends on DNA methylation. When the regions fla...

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Detalles Bibliográficos
Autores principales: Glaich, Ohad, Parikh, Shivang, Bell, Rachel E., Mekahel, Keren, Donyo, Maya, Leader, Yodfat, Shayevitch, Ronna, Sheinboim, Danna, Yannai, Sivan, Hollander, Dror, Melamed, Ze’ev, Lev-Maor, Galit, Ast, Gil, Levy, Carmit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906426/
https://www.ncbi.nlm.nih.gov/pubmed/31827083
http://dx.doi.org/10.1038/s41467-019-13527-1

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